Object-in-Place Task
Objective: Test to assess recognition memory by integrating information concerning objects and their locations
This is a Object-in-Place Task protocol using rat as the model organism. The procedure involves 5 procedural steps. Extracted from a 2007 paper published in Journal of Neuroscience.
Model and subjects
rat • DA rats • male • Not specified • Not specified • Not specified
Study window
Estimated timing pending
Core workflow
Surgical Lesion Placement • Object-in-Place Task • Novel Object Preference Task
Primary readouts
- Performance on object-in-place task (associational memory)
- Performance on novel object preference task (familiarity discrimination)
- Performance on temporal order memory task (recency discrimination)
- Performance on object location task (spatial memory control)
Key equipment and reagents
Verified items
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Protocol Steps
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Surgical Lesion Placement
Male DA rats received bilateral lesions in the perirhinal cortex (PRH) or medial prefrontal cortex (mPFC), or unilateral lesions placed in both cortices in either the same hemisphere (PRH-mPFC IPSI) or contralateral hemispheres (PRH-mPFC CONTRA). A control group underwent sham surgery (SHAM).
Note: Five experimental groups total: PRH lesion, mPFC lesion, PRH-mPFC IPSI, PRH-mPFC CONTRA, and SHAM control
View evidence from paper
“Male DA rats received bilateral lesions in the PRH or mPFC or unilateral lesions placed in both cortices in either the same (PRH–mPFC IPSI) or contralateral (PRH–mPFC CONTRA) hemispheres. A fifth group underwent sham surgery (SHAM).”
Object-in-Place Task
Rats were tested on the object-in-place task to assess recognition memory by integrating information concerning objects and their locations.
Note: This task measures associational memory requiring integration of object identity with spatial location information
View evidence from paper
“a novel object preference task, an object-in-place task, and a temporal order memory task”
Novel Object Preference Task
Rats were tested on the novel object preference task to assess discrimination between novel and familiar individual objects based on familiarity.
Note: This task measures familiarity discrimination for individual objects
View evidence from paper
“a novel object preference task, an object-in-place task, and a temporal order memory task”
Temporal Order Memory Task
Rats were tested on the temporal order memory task to assess recency discrimination and memory for the temporal sequence of events.
Note: This task measures recency information and temporal order discrimination
View evidence from paper
“a novel object preference task, an object-in-place task, and a temporal order memory task”
Object Location Task
Rats were tested on the object location task as a control measure.
Note: No group was impaired in this task, suggesting it measures different cognitive processes than the other tasks
View evidence from paper
“No group was impaired in the object location task.”