Experiments/Object Recognition Task

Source Paper

Dentate gyrus-specific knockdown of adult neurogenesis impairs spatial and object recognition memory in adult rats

Sebastian Jessberger, Robert E. Clark, Nicola J. Broadbent, Gregory D. Clemenson, Antonella Consiglio et al.

Learning & Memory • 2009

DOI PMC

Object Recognition Task

behavioralratadult male rats

Objective: Measure object recognition memory in adult rats with reduced neurogenesis in the dentate gyrus

This is a Object Recognition Task protocol using rat as the model organism. The procedure involves 2 procedural steps, 1 materials. Extracted from a 2009 paper published in Learning & Memory.

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Replication Essentials

Model and subjects

rat • adult male rats • male • adult

Study window

Estimated timing pending

Core workflow

Lentiviral injection for neurogenesis knockdown • Object recognition task

Primary readouts

Object recognition memory performance
Comparison of impairment between reduced neurogenesis and control animals

Key equipment and reagents

Lentiviral vector expressing dominant-negative WNT (dnWNT)

Procurement Snapshot

Verified items

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Protocol Steps

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Lentiviral injection for neurogenesis knockdown

Administer lentiviral vector expressing dominant-negative WNT to block neurogenesis in the dentate gyrus of adult male rats

Note: This creates the experimental condition of reduced neurogenesis for testing

View evidence from paper

“lentiviral approach to specifically block neurogenesis in the dentate gyrus of adult male rats by inhibiting WNT signaling”