Source Paper
The Role of the Extracellular Signal-Regulated Kinase Signaling Pathway in Mood Modulation
Haim Einat, Peixiong Yuan, Todd D. Gould, Jianling Li, JianHua Du et al.
Journal of Neuroscience • 2003
Open Field Test
Objective: Measurement of locomotor activity and exploratory behavior in a large open field arena to assess the effects of ERK pathway inhibition on behavioral outcomes
This is a Open Field Test protocol using rat as the model organism. The procedure involves 2 procedural steps, 1 equipment items, 4 materials. Extracted from a 2003 paper published in Journal of Neuroscience.
Model and subjects
rat • Not specified • unknown • Not specified • Not specified
Study window
Estimated timing pending
Core workflow
Drug administration • Open field testing
Primary readouts
- Locomotion time
- Distance traveled
- Exploratory behavior in open field
Key equipment and reagents
Use this page as an execution guide, then fall back to the source paper whenever you need exact exclusions, dosing details, or assay-specific caveats.
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- Verify the animal model, intervention setup, and collection timepoints against the source paper.
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- Jump to Experimental Context for readouts, data shape, and analysis flow before planning downstream analysis.
Protocol Steps
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Drug administration
Administer SL327, U0126, lithium, or amphetamine to rats according to experimental group assignment
Note: Chronic lithium pretreatment was used in one group to prevent SL327-induced behavioral changes
View evidence from paper
“SL327, but not U0126, also increased locomotion time and distance traveled in a large open field. The behavioral changes in the open field were prevented with chronic lithium pretreatment.”
Open field testing
Place rats in a large open field arena and measure locomotor activity and exploratory behavior
Note: Testing measures locomotion time and distance traveled as primary outcome measures
View evidence from paper
“increased locomotion time and distance traveled in a large open field”