Open-Field Test
Objective: Assessment of locomotor activity and sedative effects in an open arena environment to evaluate potential ketamine-like side effects of GLYX-13
This is a Open-Field Test protocol using rat as the model organism. The procedure involves 1 procedural steps, 1 equipment items. Extracted from a 2012 paper published in Neuropsychopharmacology.
Model and subjects
rat • Not specified • unknown • Not specified • Not specified
Study window
Estimated timing pending
Core workflow
Open-field test administration
Primary readouts
- Locomotor activity
- Sedative effects
- Presence or absence of ketamine-like side effects
Key equipment and reagents
Verified items
0
Direct vendor links
0
Use this page as an execution guide, then fall back to the source paper whenever you need exact exclusions, dosing details, or assay-specific caveats.
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Protocol Steps
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Open-field test administration
Rats were tested in open-field arena to assess locomotor activity and sedative effects following GLYX-13 or ketamine administration
Note: Test was used to evaluate whether GLYX-13 exhibits sedative side effects comparable to ketamine
View evidence from paper
“GLYX-13, a novel NMDAR glycine-site functional partial agonist, produces an antidepressant-like effect without exhibiting substance abuse-related, gating, and sedative side effects of ketamine in the drug discrimination, conditioned place preference, pre-pulse inhibition and open-field tests”