Source Paper
Brain-Derived Neurotrophic Factor Produces Antidepressant Effects in Behavioral Models of Depression
Yukihiko Shirayama, Andrew C.-H. Chen, Shin Nakagawa, David S. Russell, Ronald S. Duman
Journal of Neuroscience • 2002
Passive Avoidance Test
Objective: Control behavioral test to determine whether BDNF and NT-3 infusions influence learning and memory via passive avoidance testing
This is a Passive Avoidance Test protocol using rat as the model organism. The procedure involves 1 procedural steps, 1 equipment items. Extracted from a 2002 paper published in Journal of Neuroscience.
Model and subjects
rat • Not specified • Not specified • Not specified • Not specified • Not specified
Study window
Estimated timing pending
Core workflow
Passive avoidance testing
Primary readouts
- Passive avoidance performance
- Learning and memory effects from BDNF and NT-3 infusions
Key equipment and reagents
Verified items
0
Direct vendor links
0
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Protocol Steps
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Passive avoidance testing
Conduct passive avoidance test on animals that received bilateral infusions of BDNF or NT-3 into the dentate gyrus of hippocampus
Note: This is a control test to determine if BDNF and NT-3 infusions influence learning and memory. The test was conducted following infusions.
View evidence from paper
“Infusions of BDNF and NT-3 did not influence locomotor activity or passive avoidance.”