Source Paper
Double Dissociation of Basolateral and Central Amygdala Lesions on the General and Outcome-Specific Forms of Pavlovian-Instrumental Transfer
Laura H. Corbit, Bernard W. Balleine
Journal of Neuroscience • 2005
Pavlovian Cue Effects Assessment (Experiment 2)
Objective: To assess both general motivational and specific excitatory effects of Pavlovian cues in the same animal following amygdala lesions, comparing basolateral amygdala (BLA) and central nucleus (CN) lesion effects
This is a Pavlovian Cue Effects Assessment (Experiment 2) protocol using rat as the model organism. The procedure involves 4 procedural steps. Extracted from a 2005 paper published in Journal of Neuroscience.
Model and subjects
rat • Not specified • unknown • Not specified • Not specified
Study window
Estimated timing pending
Core workflow
Instrumental Training Phase • Pavlovian Conditioning Phase • Outcome Devaluation Testing
Primary readouts
- Selective sensitivity to changes in reward value of instrumental outcomes
- Selective excitatory effects of reward-related cues in PIT
- General motivational effects of Pavlovian cues
- Outcome-specific effects of Pavlovian cues
Key equipment and reagents
Verified items
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Direct vendor links
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Protocol Steps
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Instrumental Training Phase
Rats were trained to press two levers, each earning a unique food outcome
Note: Two distinct outcomes used: pellets or sucrose
View evidence from paper
“groups of BLA-, CN-, and sham-lesioned rats were first trained to press two levers, each earning a unique food outcome (pellets or sucrose)”
Pavlovian Conditioning Phase
Two auditory stimuli (tone and white noise) were paired with the same outcomes used in instrumental training
Note: Auditory cues paired with food outcomes to establish Pavlovian associations
View evidence from paper
“they were given training in which two auditory stimuli (tone and white noise) were paired with these same outcomes”
Outcome Devaluation Testing
Tests of specific satiety induced outcome devaluation were conducted
Note: Assessed sensitivity to changes in reward value
View evidence from paper
“Tests of specific satiety induced outcome devaluation”
Pavlovian-Instrumental Transfer (PIT) Testing
Tests of PIT were conducted to assess both general motivational and specific excitatory effects of Pavlovian cues in the same animal
Note: Procedure developed to measure both general motivational and outcome-specific effects within single animals
View evidence from paper
“we developed a procedure in which both the general motivational and the specific excitatory effects of pavlovian cues could be assessed in the same animal”