Source Paper
Cannabidiol Reduces the Anxiety Induced by Simulated Public Speaking in Treatment-Naïve Social Phobia Patients
Mateus M Bergamaschi, Regina Helena Costa Queiroz, Marcos Hortes Nisihara Chagas, Danielle Chaves Gomes de Oliveira, Bruno Spinosa De Martinis et al.
Neuropsychopharmacology • 2011
Physiological Monitoring
Objective: Measurement of blood pressure, heart rate, and skin conductance at six time points during a simulated public speaking test to assess physiological anxiety responses
Gather these items before starting the experiment. Check off items as you prepare.
Equipment3
Materials2
Software2
Not specified • Not mentioned
Not specified • Not mentioned
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Protocol Steps
Pre-treatment administration
Administer CBD (600 mg) or placebo to SAD patients in double-blind randomized design
Note: Double-blind procedure; healthy controls receive no medication
View evidence from paper
“24 never-treated patients with SAD were allocated to receive either CBD (600 mg; n=12) or placebo (placebo; n=12) in a double-blind randomized design 1 h and a half before the test”
Baseline physiological measurement (Time point 1)
Measure blood pressure, heart rate, and skin conductance at baseline before simulated public speaking test begins
Note: First of six measurement time points
View evidence from paper
“physiological measures (blood pressure, heart rate, and skin conductance) were measured at six different time points during the SPST”
Simulated public speaking test (SPST)
Conduct simulated public speaking test with participants
Note: Test conducted with all three groups: CBD-treated SAD patients, placebo-treated SAD patients, and healthy controls
View evidence from paper
“Each volunteer participated in only one experimental session in a double-blind procedure”
Physiological measurements during SPST (Time points 2-6)
Measure blood pressure, heart rate, and skin conductance at five additional time points during the simulated public speaking test
Note: Total of six measurement time points throughout the test
View evidence from paper
“physiological measures (blood pressure, heart rate, and skin conductance) were measured at six different time points during the SPST”
Subjective mood assessment
Administer Visual Analogue Mood Scale (VAMS) to assess subjective anxiety, cognitive impairment, discomfort, and alert levels
Note: Administered at the same six time points as physiological measures
View evidence from paper
“Subjective ratings on the Visual Analogue Mood Scale (VAMS) and Negative Self-Statement scale (SSPS-N) and physiological measures (blood pressure, heart rate, and skin conductance) were measured at six different time points”
Negative self-statement assessment
Administer Negative Self-Statement scale (SSPS-N) to assess cognitive anxiety and negative self-talk during the test
Note: Administered at the same six time points as physiological measures
View evidence from paper
“Subjective ratings on the Visual Analogue Mood Scale (VAMS) and Negative Self-Statement scale (SSPS-N) and physiological measures (blood pressure, heart rate, and skin conductance) were measured at six different time points”