Source Paper
Gut bacteria composition in animal models of Parkinson’s disease: a systematic review and meta-analysis
Elford JD, Heesbeen EJ, van der Plaats NA, Garssen J, Kraneveld AD et al.
NPJ Parkinsons Dis • 2026
Pole Test
Objective: Cannot be determined - this is a systematic review methods section, not an experimental protocol
This is a Pole Test protocol using Not specified as the model organism. The procedure involves 6 procedural steps. Extracted from a 2026 paper published in NPJ Parkinsons Dis.
Model and subjects
Not specified • Not specified • Not specified • Not specified • Not specified
Study window
Estimated timing pending
Core workflow
Protocol Registration • Database Search • Reference Processing
Primary readouts
- time to descend (pole test)
- α-diversity richness (Chao1, ACE, Observed species, Sobs index)
- α-diversity evenness (Simpson, Shannon, Faith's index, PD whole tree)
- β-Diversity relative abundance of bacteria
Key equipment and reagents
Verified items
0
Direct vendor links
0
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- Verify the animal model, intervention setup, and collection timepoints against the source paper.
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- Jump to Experimental Context for readouts, data shape, and analysis flow before planning downstream analysis.
Protocol Steps
Start here. The step list is optimized for running the experiment, with direct vendor links available inline when you need to source a cited item.
Protocol Registration
Systematic review protocol was preregistered and published
Note: Protocol submitted February 24, 2024 and published March 13, 2024
View evidence from paper
“This systematic review was performed in concordance with a preregistered protocol (PROSPERO, CRD42024510870)”
Database Search
Systematic search performed in Medline/PubMed and Embase databases
Note: Both databases accessed on February 29, 2024
View evidence from paper
“A systematic search of the literature was performed in the medical databases of Medline/PubMed and Embase”
Reference Processing
References downloaded and de-duplicated
Note: Used EndNote software for processing
View evidence from paper
“references were downloaded and de-duplicated using EndNote”
Study Screening
Two-phase screening performed by two independent reviewers using title/abstract then full text
Note: Conflicts resolved by third reviewer
View evidence from paper
“Screening of articles was performed by two reviewers in an independent manner (JDE and NAvdP)”
Data Extraction
Data extracted from included studies according to predefined characteristics
Note: Two reviewers extracted data with mutual verification
View evidence from paper
“Two reviewers extracted the data from the included articles (JDE and NAvdP), with each author verifying the extracted data from the other”
Meta-Analysis
Random effects model meta-analysis performed using R software
Note: Three-level meta-analysis with standardized mean differences
View evidence from paper
“We applied a random effects model to account for variation in the true effect size”