GLYX-13, a NMDA Receptor Glycine-Site Functional Partial Agonist, Induces Antidepressant-Like Effects Without Ketamine-Like Side Effects

Jeffrey Burgdorf, Xiao-lei Zhang, Katherine L Nicholson, Robert L Balster, J David Leander et al.

Neuropsychopharmacology • 2012

DOI PMC

Porsolt Forced Swim Test

behavioralratNot specified

Objective: Assessment of antidepressant-like effects through measurement of immobility in rats subjected to forced swimming

Materials & Equipment Checklist

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Equipment1

Porsolt Forced Swim Test apparatus

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Protocol Steps

Porsolt Forced Swim Test

Rats are subjected to forced swimming to assess antidepressant-like effects. The test measures immobility as an indicator of depressive-like behavior.

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Forced Swim Test Apparatus

Matches: Porsolt Forced Swim Test apparatus

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Note: This test was used to evaluate the antidepressant-like effects of GLYX-13 in comparison to ketamine

View evidence from paper

“produces an antidepressant-like effect in the Porsolt, novelty induced hypophagia, and learned helplessness tests in rats”