Progressive Ratio Operant Conditioning
Objective: Measurement of motivated behavior for sucrose reward under increasing response requirements following peripheral Exendin-4 administration to assess the impact of GLP-1 agonist on food reward in the mesolimbic reward system
Gather these items before starting the experiment. Check off items as you prepare.
Equipment1
Not specified • Not specified • Not specified • Not specified
Materials3
Software1
Not specified • Not specified
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Protocol Steps
Peripheral Exendin-4 Administration
Administer Exendin-4 peripherally to rats prior to progressive ratio operant conditioning task
Note: Administration route is peripheral (not central or intramesolimbic)
View evidence from paper
“EX4 also decreased motivated behavior for sucrose in a progressive ratio operant-conditioning paradigm when administered peripherally”
Progressive Ratio Operant Conditioning Task
Place rats in operant conditioning apparatus and measure motivated behavior for sucrose reward under increasing response requirements
Note: Task measures food reward motivation and the impact of EX4 on reward-seeking behavior
View evidence from paper
“EX4 also decreased motivated behavior for sucrose in a progressive ratio operant-conditioning paradigm when administered peripherally”