Objective: Establish baseline cognitive function and psychiatric status in patients with Alzheimer's disease prior to enrollment in a blood-brain barrier opening study
This is a Psychometric Testing protocol using human as the model organism. The procedure involves 7 procedural steps, 3 equipment items, 2 materials. Extracted from a 2018 paper published in Nature Communications.
Model and subjects
human • unknown • 50-85 years • 21
Study window
Estimated timing pending
Core workflow
Patient screening and referral • Informed consent • Cognitive diagnosis confirmation
Primary readouts
Key equipment and reagents
Verified items
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Direct vendor links
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Patients between age 50 and 85 with mild-to-moderate AD were referred to the study by neurologists and geriatricians
Note: Inclusion criteria: MMSE score equal to or greater than 18
“Patients between age 50 and 85 with mild-to-moderate AD with an MMSE score equal to or greater than 18 were eligible for the study. In general, patients were referred to the study by neurologists and geriatricians”
Prior to enrollment, all patients and their primary caregivers provided informed consent to the study and publication of radiologic images
“Prior to enrollment, all patients and their primary caregivers provided informed consent to the study, and publication of radiologic images”
Confirmation of Alzheimer's disease diagnosis by an expert in cognitive neurology
“During screening, patients underwent confirmation of their diagnosis by an expert in cognitive neurology”
Pre-surgical anesthetic evaluation conducted during screening phase
“During screening, patients underwent confirmation of their diagnosis by an expert in cognitive neurology, a pre-surgical anesthetic evaluation, baseline psychometric tests”
Administration of baseline psychometric tests to establish cognitive function. Tests include Mini Mental State Exam (MMSE score 18-28), Short form Geriatric Depression Scale (score ≤6), and Modified Hachinski Ischemia Scale (score ≤4)
“baseline psychometric tests, and radiographic investigations with CT, MRI, and [18F]-florbetaben PET CT scans. Mini Mental State Exam 18–28, Short form Geriatric Depression Scale ≤6, Modified Hachinski Ischemia Scale ≤4”
Patients underwent CT, MRI, and [18F]-florbetaben PET CT scans to assess for contraindications and confirm beta-amyloid deposition in the right frontal lobe
“radiographic investigations with CT, MRI, and [18F]-florbetaben PET CT scans”
Evaluation of exclusion criteria including contraindications to MRI/contrast agents, MRI findings of active neurological processes, cardiac disease, hypertension, bleeding predisposition, cerebral/systemic vasculopathy, psychiatric symptoms on NPI-Q, renal function, and respiratory disorders
“They were excluded if they had any contraindications to MRI, gadolinium or ultrasound contrast (Definity®), increased risk of bleeding, active intracranial diseases such as brain tumors or vascular malformations, or significant cardiovascular, pulmonary, and renal disease”
This section explains what the experiment is doing, which readouts matter, what the data artifacts usually look like, and how the analysis should flow from raw capture to reported result.
Establish baseline cognitive function and psychiatric status in patients with Alzheimer's disease prior to enrollment in a blood-brain barrier opening study
Objective
Establish baseline cognitive function and psychiatric status in patients with Alzheimer's disease prior to enrollment in a blood-brain barrier opening study
Subjects
From paperhuman • unknown • 50-85 years
Sample count
From paper21
Cohort notes
From paperPatients with mild-to-moderate Alzheimer's disease; 5 of 21 screened patients completed the study between March and September 2017
Patient screening and referral
Informed consent
Cognitive diagnosis confirmation
Pre-surgical anesthetic evaluation
Mini Mental State Exam (MMSE) score (range 18-28)
From paperNot specified in the provided text
Artifact type
Endpoint measurements summarized by group or timepoint
Comparison focus
Compare endpoint magnitude between groups, timepoints, or both
Short form Geriatric Depression Scale score (≤6)
From paperNot specified in the provided text
Artifact type
Endpoint measurements summarized by group or timepoint
Comparison focus
Compare endpoint magnitude between groups, timepoints, or both
Modified Hachinski Ischemia Scale score (≤4)
From paperNot specified in the provided text
Artifact type
Endpoint measurements summarized by group or timepoint
Comparison focus
Compare endpoint magnitude between groups, timepoints, or both
Neuropsychiatric Inventory Questionnaire (NPI-Q) subscale scores for Delusion, Hallucination, and Agitation/Aggression
From paperNot specified in the provided text
Artifact type
Endpoint measurements summarized by group or timepoint
Comparison focus
Compare endpoint magnitude between groups, timepoints, or both
Mini Mental State Exam (MMSE) score (range 18-28)
From paperRaw artifact
Per-sample or per-animal endpoint measurements collected during the experiment
Processed artifact
Structured table with cleaned measurements ready for comparison
Final reported form
Summary statistics and between-group or across-timepoint comparisons
Short form Geriatric Depression Scale score (≤6)
From paperRaw artifact
Per-sample or per-animal endpoint measurements collected during the experiment
Processed artifact
Structured table with cleaned measurements ready for comparison
Final reported form
Summary statistics and between-group or across-timepoint comparisons
Modified Hachinski Ischemia Scale score (≤4)
From paperRaw artifact
Per-sample or per-animal endpoint measurements collected during the experiment
Processed artifact
Structured table with cleaned measurements ready for comparison
Final reported form
Summary statistics and between-group or across-timepoint comparisons
Neuropsychiatric Inventory Questionnaire (NPI-Q) subscale scores for Delusion, Hallucination, and Agitation/Aggression
From paperRaw artifact
Per-sample or per-animal endpoint measurements collected during the experiment
Processed artifact
Structured table with cleaned measurements ready for comparison
Final reported form
Summary statistics and between-group or across-timepoint comparisons
Acquisition
Collect raw experimental outputs with enough metadata to preserve sample identity, condition, and timing.
Preprocessing / cleaning
Not specified in the provided text
Scoring or quantification
Quantify the primary readouts for this experiment: Mini Mental State Exam (MMSE) score (range 18-28); Short form Geriatric Depression Scale score (≤6); Modified Hachinski Ischemia Scale score (≤4); Neuropsychiatric Inventory Questionnaire (NPI-Q) subscale scores for Delusion, Hallucination, and Agitation/Aggression.
Statistical comparison
Statistical method not yet structured for this page.
Reporting output
Report representative outputs alongside summary comparisons for Mini Mental State Exam (MMSE) score (range 18-28), Short form Geriatric Depression Scale score (≤6), Modified Hachinski Ischemia Scale score (≤4), Neuropsychiatric Inventory Questionnaire (NPI-Q) subscale scores for Delusion, Hallucination, and Agitation/Aggression.
Source links and direct wording from the methods section for validation and deeper review.
Citation
Nir Lipsman et al. (2018). Blood–brain barrier opening in Alzheimer’s disease using MR-guided focused ultrasound. Nature Communications
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Lantheus Medical Technologies
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Current status surfaces were computed from experiment data updated Feb 28, 2026.
Source access
Jump back into the original paper or the methods evidence section when you need exact wording, exclusions, or method-specific caveats.
This protocol has structured steps plus evidence quotes, and is ready for canonical sync.
Steps
7
Evidence Quotes
12
Protocol Items
5
Linked Products
0
Canonical Sync
Pending
What this means
The completeness score reflects how much structured protocol data is present: steps, methods evidence, listed materials, linked products, and paper provenance.
Computed from the current experiment record updated Feb 28, 2026.
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Steps
7
Evidence
12
Specific Products
0/0
Canonical Sync
Pending
What this score means
The verification score reflects evidence coverage, subject detail, paper provenance, step depth, and whether linked products resolve to specific item pages instead of generic searches.
Computed from the current experiment record updated Feb 28, 2026.
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