Pure-Tone Exposure and Auditory Cortex Mapping
Objective: Examine effects of pure-tone exposure on auditory cortex of developing rat pups at different postnatal ages to determine critical period for spectral tuning plasticity
This is a Pure-Tone Exposure and Auditory Cortex Mapping protocol using rat as the model organism. The procedure involves 3 procedural steps, 1 equipment items. Extracted from a 2007 paper published in Journal of Neuroscience.
Model and subjects
rat • not specified • unknown • postnatal day 11 (P11) to P13 and other postnatal ages • not specified
Study window
Estimated timing pending
Core workflow
Pure-Tone Exposure During Critical Period • Auditory Cortex Mapping • Measure Sound Intensity Representation
Primary readouts
- Alterations in sound representations in primary auditory cortex (A1)
- Changes in cortical representation of sound frequency
- Changes in cortical representation of sound intensity
- Persistence of plasticity-induced changes
Key equipment and reagents
Verified items
0
Direct vendor links
0
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Protocol Steps
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Pure-Tone Exposure During Critical Period
Expose developing rat pups to pure-tone stimulation during the critical period window
Note: Pure-tone exposure resulted in profound, persistent alterations in sound representations in A1 only during postnatal day 11 (P11) to P13
View evidence from paper
“pure-tone exposure resulted in profound, persistent alterations in sound representations in A1 only if the exposure occurred during a brief period extending from postnatal day 11 (P11) to P13”
Auditory Cortex Mapping
Map the auditory cortex of exposed and control rat pups to measure alterations in sound representations
Note: High temporal resolution examination of effects at different postnatal ages
View evidence from paper
“examined the effects of pure-tone exposure on the auditory cortex of developing rat pups at different postnatal ages with a high temporal resolution”
Measure Sound Intensity Representation
Assess alterations in cortical representation of sound intensity following postnatal sound exposure
Note: Striking alterations in cortical representation of sound intensity were observed
View evidence from paper
“postnatal sound exposure in this epoch led to striking alterations in the cortical representation of sound intensity”