Source Paper
An Animal Model of Genetic Vulnerability to Behavioral Disinhibition and Responsiveness to Reward-Related Cues: Implications for Addiction
Shelly B Flagel, Terry E Robinson, Jeremy J Clark, Sarah M Clinton, Stanley J Watson et al.
Neuropsychopharmacology • 2009
Quinpirole Psychomotor Activation Test
Objective: Assessment of psychomotor activation in response to dopamine agonist quinpirole to test dopamine supersensitivity in bred high-responder (bHR) versus bred low-responder (bLR) rats
Gather these items before starting the experiment. Check off items as you prepare.
Materials1
Not specified • Not specified • Not specified • Not mentioned
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Protocol Steps
Administer quinpirole
Administer dopamine agonist quinpirole to selectively bred high-responder and low-responder rats
Note: Dosage and route of administration not specified in provided text
View evidence from paper
“The dopamine agonist quinpirole caused greater psychomotor activation in bHRs relative to bLRs, suggesting dopamine supersensitivity.”
Measure psychomotor activation
Assess and compare psychomotor activation responses between bred high-responder and bred low-responder rats following quinpirole administration
Note: Specific measurement methodology and equipment not detailed in provided text
View evidence from paper
“The dopamine agonist quinpirole caused greater psychomotor activation in bHRs relative to bLRs, suggesting dopamine supersensitivity.”