Source Paper
An Animal Model of Genetic Vulnerability to Behavioral Disinhibition and Responsiveness to Reward-Related Cues: Implications for Addiction
Shelly B Flagel, Terry E Robinson, Jeremy J Clark, Sarah M Clinton, Stanley J Watson et al.
Neuropsychopharmacology • 2009
Quinpirole Psychomotor Activation Test
Objective: Assessment of psychomotor activation in response to dopamine agonist quinpirole to test dopamine supersensitivity in bred high-responder (bHR) versus bred low-responder (bLR) rats
This is a Quinpirole Psychomotor Activation Test protocol using rat as the model organism. The procedure involves 2 procedural steps, 1 materials. Extracted from a 2009 paper published in Neuropsychopharmacology.
Model and subjects
rat • Selectively bred high-responder and low-responder lines • unknown • Not specified • Not specified
Study window
Estimated timing pending
Core workflow
Administer quinpirole • Measure psychomotor activation
Primary readouts
- Psychomotor activation response to quinpirole
- Comparison of activation levels between bred high-responder and bred low-responder rats
- Evidence of dopamine supersensitivity in bHRs
Key equipment and reagents
Verified items
0
Direct vendor links
0
Use this page as an execution guide, then fall back to the source paper whenever you need exact exclusions, dosing details, or assay-specific caveats.
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Protocol Steps
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Administer quinpirole
Administer dopamine agonist quinpirole to selectively bred high-responder and low-responder rats
Note: Dosage and route of administration not specified in provided text
View evidence from paper
“The dopamine agonist quinpirole caused greater psychomotor activation in bHRs relative to bLRs, suggesting dopamine supersensitivity.”
Measure psychomotor activation
Assess and compare psychomotor activation responses between bred high-responder and bred low-responder rats following quinpirole administration
Note: Specific measurement methodology and equipment not detailed in provided text
View evidence from paper
“The dopamine agonist quinpirole caused greater psychomotor activation in bHRs relative to bLRs, suggesting dopamine supersensitivity.”