Source Paper
Inflammation-targeted single-atom nanozymes drive microglial depolarization and inhibit ferroptosis via Sirt-6-xCT-GPX4 axis to attenuate early brain injury following subarachnoid hemorrhage
Liu B, Xiang C, Zhang X, Guo W, Wu H et al.
Mater Today Bio • 2026
SAH Model Survival Assessment
behavioralMiceNot specified
Objective: Assessment of survival rates and therapeutic effects in subarachnoid hemorrhage (SAH) model mice following treatment with biomimetic nanozyme NM@V-MDL-800
Protocol Steps
1
SAH Model Creation
Establish subarachnoid hemorrhage model in mice
View evidence from paper
“The therapeutic effect of NM@V-MDL-800 on the SAH model”
2
Tail Vein Injection
Administer NM@V-MDL-800 treatment via intravenous injection through tail vein
View evidence from paper
“intravenous injection through the tail vein NM@V-MDL-800 can alleviate oxidative stress”
3
In Vivo Imaging Assessment
Monitor BBB penetration and targeting using Cy5-labeled NM@V-MDL-800
View evidence from paper
“in vivo imaging of mice showed that anthocyanin-5 (Cy5)-labeled NM@V-MDL-800 had excellent BBB penetration”
4
Survival Rate Monitoring
Assess survival rates following SAH and treatment
View evidence from paper
“NM@V-MDL-800 can improve the survival rate after SAH”
5
Cognitive Function Assessment
Evaluate cognitive and memory function improvements
View evidence from paper
“NM@V-MDL-800 can improve the survival rate after SAH and improve cognitive and memory function”