Source Paper
Inflammation-targeted single-atom nanozymes drive microglial depolarization and inhibit ferroptosis via Sirt-6-xCT-GPX4 axis to attenuate early brain injury following subarachnoid hemorrhage
Liu B, Xiang C, Zhang X, Guo W, Wu H et al.
Mater Today Bio • 2026
SAH Model Survival Assessment
Objective: Assessment of survival rates and therapeutic effects in subarachnoid hemorrhage (SAH) model mice following treatment with biomimetic nanozyme NM@V-MDL-800
This is a SAH Model Survival Assessment protocol using Mice as the model organism. The procedure involves 5 procedural steps, 1 equipment items, 2 materials. Extracted from a 2026 paper published in Mater Today Bio.
Model and subjects
Mice • Not specified • Not specified • Not specified • Not specified
Study window
Estimated timing pending
Core workflow
SAH Model Creation • Tail Vein Injection • In Vivo Imaging Assessment
Primary readouts
- Survival rate after SAH
- BBB penetration efficiency
- Targeted aggregation at bleeding injury site
- Cognitive and memory function improvement
Key equipment and reagents
Use this page as an execution guide, then fall back to the source paper whenever you need exact exclusions, dosing details, or assay-specific caveats.
Confirm first
- Verify the animal model, intervention setup, and collection timepoints against the source paper.
- Check that every direct vendor link matches the exact specification your lab plans to run.
Use the page like this
- Work through the protocol steps in order and use the inline vendor chips only when you need to source or verify an item.
- Jump to Experimental Context for readouts, data shape, and analysis flow before planning downstream analysis.
Protocol Steps
Start here. The step list is optimized for running the experiment, with direct vendor links available inline when you need to source a cited item.
SAH Model Creation
Establish subarachnoid hemorrhage model in mice
View evidence from paper
“The therapeutic effect of NM@V-MDL-800 on the SAH model”
Tail Vein Injection
Administer NM@V-MDL-800 treatment via intravenous injection through tail vein
View evidence from paper
“intravenous injection through the tail vein NM@V-MDL-800 can alleviate oxidative stress”
In Vivo Imaging Assessment
Monitor BBB penetration and targeting using Cy5-labeled NM@V-MDL-800
View evidence from paper
“in vivo imaging of mice showed that anthocyanin-5 (Cy5)-labeled NM@V-MDL-800 had excellent BBB penetration”
Survival Rate Monitoring
Assess survival rates following SAH and treatment
View evidence from paper
“NM@V-MDL-800 can improve the survival rate after SAH”
Cognitive Function Assessment
Evaluate cognitive and memory function improvements
View evidence from paper
“NM@V-MDL-800 can improve the survival rate after SAH and improve cognitive and memory function”