Scopolamine Sensitivity Testing
Objective: Assessment of sensitivity to cholinergic antagonist scopolamine injections during delayed nonmatching-to-sample performance to evaluate central cholinergic system function in basal forebrain lesioned monkeys
Protocol Steps
Baseline delayed nonmatching-to-sample task performance
Establish baseline accuracy in delayed nonmatching-to-sample task prior to scopolamine testing
Note: This establishes control performance against which scopolamine effects are measured
View evidence from paper
“BFCS lesions increased sensitivity to injections of the cholinergic antagonist scopolamine in a delayed nonmatching-to-sample task”
Scopolamine injection
Administer scopolamine injections to test sensitivity of cholinergic system
Note: Injection route, dose, and timing not specified in provided text
View evidence from paper
“BFCS lesions increased sensitivity to injections of the cholinergic antagonist scopolamine in a delayed nonmatching-to-sample task”
Delayed nonmatching-to-sample task performance assessment
Assess accuracy in delayed nonmatching-to-sample task following scopolamine injection to measure cholinergic antagonist effects
Note: Compare performance to baseline to determine sensitivity to scopolamine
View evidence from paper
“BFCS lesions increased sensitivity to injections of the cholinergic antagonist scopolamine in a delayed nonmatching-to-sample task, indicating that the central cholinergic system was compromised”