Experiments/Spatial Discrimination Task

Source Paper

Basal forebrain lesions in monkeys disrupt attention but not learning and memory [published erratum appears in J Neurosci 1995 Mar;15(3): following table of contents]

ML Voytko, DS Olton, RT Richardson, LK Gorman, JR Tobin et al.

Journal of Neuroscience • 1994

DOI PMC

Spatial Discrimination Task

behavioralcynomolgus monkeys

Objective: Evaluate the effects of basal forebrain cholinergic system lesions on spatial discrimination abilities in monkeys

This is a Spatial Discrimination Task protocol using cynomolgus monkeys as the model organism. The procedure involves 3 procedural steps, 2 materials. Extracted from a 1994 paper published in Journal of Neuroscience.

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Replication Essentials

Model and subjects

cynomolgus monkeys

Study window

Estimated timing pending

Core workflow

Surgical lesioning procedure • Spatial discrimination task administration • Scopolamine sensitivity assessment

Primary readouts

Accuracy in spatial discrimination tasks
Attentional focusing ability
Sensitivity to scopolamine in delayed nonmatching-to-sample task
Performance on delayed nonmatching-to-sample

Key equipment and reagents

Ibotenic acidScopolamine

Before You Start

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Protocol Steps

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Surgical lesioning procedure

Ibotenic acid injections administered to medial septum, nucleus of the diagonal band of Broca, and nucleus basalis of Meynert in cynomolgus monkeys

Note: This is a surgical intervention to create basal forebrain cholinergic system lesions

View evidence from paper

“ibotenic acid injections in the medial septum, nucleus of the diagonal band of Broca, and nucleus basalis of Meynert in cynomolgus monkeys”