Visual Discrimination Tasks
Objective: To evaluate the effects of basal forebrain cholinergic system (BFCS) lesions on cognitive processes in monkeys, specifically examining different mnemonic and attentional abilities through a series of cognitive tasks
This is a Visual Discrimination Tasks protocol using cynomolgus monkeys as the model organism. The procedure involves 6 procedural steps, 2 materials. Extracted from a 1994 paper published in Journal of Neuroscience.
Model and subjects
cynomolgus monkeys
Study window
Estimated timing pending
Core workflow
Surgical lesion creation • Cognitive task battery administration • Simple visual discrimination task
Primary readouts
- Accuracy in delayed nonmatching-to-sample task
- Accuracy in delayed response task
- Accuracy in simple visual discrimination
- Accuracy in concurrent visual discrimination
Key equipment and reagents
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Protocol Steps
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Surgical lesion creation
Ibotenic acid injections administered to the medial septum, nucleus of the diagonal band of Broca, and nucleus basalis of Meynert in cynomolgus monkeys
Note: Lesions were created in basal forebrain cholinergic system regions
View evidence from paper
“ibotenic acid injections in the medial septum, nucleus of the diagonal band of Broca, and nucleus basalis of Meynert in cynomolgus monkeys”
Cognitive task battery administration
Systematic investigation of behavioral effects using a large series of cognitive tasks examining different mnemonic and attentional abilities
Note: Tasks included delayed nonmatching-to-sample, delayed response, simple visual discriminations, concurrent visual discriminations, spatial discriminations, and discrimination reversals
View evidence from paper
“using a large series of cognitive tasks that examined different mnemonic and attentional abilities”
Simple visual discrimination task
Assessment of learning and discrimination abilities using simple visual discrimination
Note: Lesions did not impair accuracy in this task
View evidence from paper
“simple or concurrent visual discriminations”
Concurrent visual discrimination task
Assessment of learning and discrimination abilities using concurrent visual discrimination
Note: Lesions did not impair accuracy in this task
View evidence from paper
“simple or concurrent visual discriminations”
Discrimination reversal task
Assessment of cognitive flexibility through discrimination reversals
Note: Lesions did not impair accuracy in discrimination reversals
View evidence from paper
“discrimination reversals”
Scopolamine sensitivity testing
Evaluation of central cholinergic system compromise by testing sensitivity to cholinergic antagonist injections in delayed nonmatching-to-sample task
Note: BFCS lesioned monkeys showed increased sensitivity to scopolamine
View evidence from paper
“BFCS lesions increased sensitivity to injections of the cholinergic antagonist scopolamine in a delayed nonmatching-to-sample task”