Orexin A/Hypocretin-1 Selectively Promotes Motivation for Positive Reinforcers

Stephanie L. Borgland, Shao-Ju Chang, M. Scott Bowers, Jennifer L. Thompson, Nicole Vittoz et al.

Journal of Neuroscience • 2009

DOI PMC

Self-Administration Test

behavioralratNot specified

Objective: Measurement of work and motivation to self-administer cocaine or high fat food pellets, and effects of orexin receptor blockade on this behavior

Protocol Steps

Self-Administration Test Setup

Rats were tested for work and motivation to self-administer cocaine or high fat food pellets

Not specifiedNot specified

Note: The experiment measured motivation for positive reinforcers under orexin receptor blockade conditions

View evidence from paper

“Blockade of ox/hcrt-1R selectively reduced work to self-administer cocaine or high fat food pellets”

Measurement of Motivated Behavior

Work output was measured to assess motivation for self-administration of cocaine or high fat food pellets

Not specifiedNot specified

Note: Orexin receptor blockade selectively reduced work for these reinforcers

View evidence from paper

“Blockade of ox/hcrt-1R selectively reduced work to self-administer cocaine or high fat food pellets”