Self-Administration Test
Objective: Measurement of work and motivation to self-administer cocaine or high fat food pellets, and effects of orexin receptor blockade on this behavior
This is a Self-Administration Test protocol using rat as the model organism. The procedure involves 2 procedural steps. Extracted from a 2009 paper published in Journal of Neuroscience.
Model and subjects
rat • Not specified • unknown • Not specified • Not specified
Study window
Estimated timing pending
Core workflow
Self-Administration Test Setup • Measurement of Motivated Behavior
Primary readouts
- Work output for cocaine self-administration
- Work output for high fat food pellet self-administration
- Effects of orexin receptor blockade on motivation
- Presynaptic glutamatergic inputs to ventral tegmental area (VTA)
Key equipment and reagents
Verified items
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Direct vendor links
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Protocol Steps
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Self-Administration Test Setup
Rats were tested for work and motivation to self-administer cocaine or high fat food pellets
Note: The experiment measured motivation for positive reinforcers under orexin receptor blockade conditions
View evidence from paper
“Blockade of ox/hcrt-1R selectively reduced work to self-administer cocaine or high fat food pellets”
Measurement of Motivated Behavior
Work output was measured to assess motivation for self-administration of cocaine or high fat food pellets
Note: Orexin receptor blockade selectively reduced work for these reinforcers
View evidence from paper
“Blockade of ox/hcrt-1R selectively reduced work to self-administer cocaine or high fat food pellets”