Source Paper
An Animal Model of Genetic Vulnerability to Behavioral Disinhibition and Responsiveness to Reward-Related Cues: Implications for Addiction
Shelly B Flagel, Terry E Robinson, Jeremy J Clark, Sarah M Clinton, Stanley J Watson et al.
Neuropsychopharmacology • 2009
Sign Tracking and Goal Tracking Task
Objective: To assess whether rats learn to approach cues paired with reward (sign tracking) versus the location of reward delivery (goal tracking), and to characterize differences between bred high-responder and bred low-responder rats in their attribution of incentive value to reward-related cues
This is a Sign Tracking and Goal Tracking Task protocol using rat as the model organism. The procedure involves 1 procedural steps. Extracted from a 2009 paper published in Neuropsychopharmacology.
Model and subjects
rat • Bred high-responder (bHR) and bred low-responder (bLR) lines selectively bred based on reactivity to novel environment • unknown • Not specified • Not specified
Study window
Estimated timing pending
Core workflow
Cue-Reward Pairing Task
Primary readouts
- Approach behavior to cue (sign tracking)
- Approach behavior to reward location (goal tracking)
- Attribution of incentive value to reward-related cues
- Impulsive behavior measures
Key equipment and reagents
Verified items
0
Direct vendor links
0
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Protocol Steps
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Cue-Reward Pairing Task
A cue was paired with food or cocaine reward. Rats were observed to determine whether they learned to approach the cue (sign tracking) or the location of food delivery (goal tracking).
Note: bHR rats learned to approach the cue, while bLR rats learned to approach the location of food delivery
View evidence from paper
“When a cue was paired with food or cocaine reward bred high-responder rats (bHRs) learned to approach the cue, whereas bred low-responder rats (bLRs) learned to approach the location of food delivery”