Source Paper
Reduced fear expression after lesions of the ventral hippocampus
Kirsten G. Kjelstrup, Frode A. Tuvnes, Hill-Aina Steffenach, Robert Murison, Edvard I. Moser et al.
Proceedings of the National Academy of Sciences • 2002
Stress Response Measurement
Objective: Measurement of neuroendocrine stress responses including corticosterone levels during confinement to a brightly lit chamber in rats with and without hippocampal lesions
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Protocol Steps
Confinement to brightly lit chamber
Rats are confined to a brightly lit chamber to induce stress response
Note: This procedure is used to measure neuroendocrine stress responses
View evidence from paper
“decreased neuroendocrine stress responses during confinement to a brightly lit chamber”
Measurement of corticosterone levels
Neuroendocrine stress responses are measured, specifically corticosterone levels
Note: Corticosterone is a stress hormone measured as an indicator of neuroendocrine response
View evidence from paper
“decreased neuroendocrine stress responses during confinement to a brightly lit chamber”
Elevated plus-maze testing
Rats are tested on an elevated plus-maze to assess fear-related avoidance behavior
Note: Open arm avoidance is measured as an indicator of unconditioned fear
View evidence from paper
“Rats with selective hippocampal lesions failed to avoid open arms in an elevated plus-maze”