Stroke Model - Infarct Volume Measurement
Objective: Assessment of infarct volume reduction in rat models of acute stroke following G-CSF treatment
Protocol Steps
Stroke Model Induction
Acute stroke was induced in rats using two different models
Note: The specific methods for stroke induction are not detailed in the provided text excerpt
View evidence from paper
“G-CSF passes the intact blood-brain barrier and reduces infarct volume in 2 different rat models of acute stroke”
G-CSF Treatment Administration
G-CSF was administered to treated animals following stroke induction
Note: Specific dosage, route of administration, and timing relative to stroke are not detailed in the provided text excerpt
View evidence from paper
“G-CSF passes the intact blood-brain barrier and reduces infarct volume in 2 different rat models of acute stroke”
Infarct Volume Measurement
Infarct volume was assessed and compared between G-CSF treated and control groups
Note: The specific measurement methodology and timing are not detailed in the provided text excerpt
View evidence from paper
“G-CSF reduces infarct volume in 2 different rat models of acute stroke”
Long-term Behavioral Assessment
Long-term behavioral outcomes were evaluated following cortical ischemia and G-CSF treatment
Note: Specific behavioral tests and timing are not detailed in the provided text excerpt
View evidence from paper
“G-CSF markedly improved long-term behavioral outcome after cortical ischemia”