Stroke Model - Infarct Volume Measurement
Objective: Assessment of infarct volume reduction in rat models of acute stroke following G-CSF treatment
This is a Stroke Model - Infarct Volume Measurement protocol using rat as the model organism. The procedure involves 4 procedural steps. Extracted from a 2005 paper published in Journal of Clinical Investigation.
Model and subjects
rat • Not specified in provided text • unknown • Not specified in provided text • Not specified in provided text
Study window
Estimated timing pending
Core workflow
Stroke Model Induction • G-CSF Treatment Administration • Infarct Volume Measurement
Primary readouts
- Infarct volume reduction
- Long-term behavioral outcome
- Neural progenitor response in vivo
Key equipment and reagents
Verified items
0
Direct vendor links
0
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Protocol Steps
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Stroke Model Induction
Acute stroke was induced in rats using two different models
Note: The specific methods for stroke induction are not detailed in the provided text excerpt
View evidence from paper
“G-CSF passes the intact blood-brain barrier and reduces infarct volume in 2 different rat models of acute stroke”
G-CSF Treatment Administration
G-CSF was administered to treated animals following stroke induction
Note: Specific dosage, route of administration, and timing relative to stroke are not detailed in the provided text excerpt
View evidence from paper
“G-CSF passes the intact blood-brain barrier and reduces infarct volume in 2 different rat models of acute stroke”
Infarct Volume Measurement
Infarct volume was assessed and compared between G-CSF treated and control groups
Note: The specific measurement methodology and timing are not detailed in the provided text excerpt
View evidence from paper
“G-CSF reduces infarct volume in 2 different rat models of acute stroke”
Long-term Behavioral Assessment
Long-term behavioral outcomes were evaluated following cortical ischemia and G-CSF treatment
Note: Specific behavioral tests and timing are not detailed in the provided text excerpt
View evidence from paper
“G-CSF markedly improved long-term behavioral outcome after cortical ischemia”