Source Paper
Impaired prepulse inhibition of acoustic and tactile startle response in patients with Huntington's disease.
N R Swerdlow, J Paulsen, D L Braff, N Butters, M A Geyer et al.
Journal of Neurology Neurosurgery & Psychiatry • 1995
Stroop Test
Objective: Measurement of interference effects and performance disruption correlated with startle reflex latency in Huntington's disease patients using the Stroop test
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Protocol Steps
Measure prepulse inhibition of startle response
Measure prepulse inhibition (PPI) in patients with Huntington's disease using acoustic and tactile stimuli to quantify sensorimotor gating
Note: Startle reflex is normally inhibited when the startling stimulus is preceded 30-500 ms earlier by a weak prepulse
View evidence from paper
“prepulse inhibition (PPI) was measured in patients with Huntington's disease to quantify and characterise sensorimotor gating”
Administer Stroop test
Administer the Stroop test to measure performance disruption and interference effects in patients
Note: Performance on this test correlates with startle reflex latency
View evidence from paper
“performance disruptive effects of interference measured by the Stroop test”
Measure startle reflex latency
Record startle reflex latency in response to acoustic or tactile stimuli
Note: Reflex latency is significantly slowed in Huntington's disease patients
View evidence from paper
“reflex latency is significantly slowed”
Vary prepulse interval and intensity
Test startle gating by changing the prepulse interval and intensity to assess modulatory effects
Note: Huntington's disease patients show little or no PPI even with stimuli that elicit maximal PPI in normal subjects
View evidence from paper
“pattern of startle gating does not show the normal modulatory effects usually elicited by changing the prepulse interval or intensity”
Measure startle amplitude and habituation
Assess startle amplitude and habituation patterns in response to repeated stimuli
Note: Startle amplitude and habituation are largely intact in Huntington's disease patients
View evidence from paper
“Startle amplitude and habituation and latency facilitation are largely intact in these patients”