Source Paper
Reduction of Adult Hippocampal Neurogenesis Confers Vulnerability in an Animal Model of Cocaine Addiction
Michele A. Noonan, Sarah E. Bulin, Dwain C. Fuller, Amelia J. Eisch
Journal of Neuroscience • 2010
Sucrose Self-Administration
Objective: Assess general learning and motivation in rats through sucrose self-administration as a control measure to determine if changes in behavior are specific to drug-taking or represent general learning/motivation deficits
This is a Sucrose Self-Administration protocol using rat as the model organism. The procedure involves 1 procedural steps, 1 equipment items. Extracted from a 2010 paper published in Journal of Neuroscience.
Model and subjects
rat • not specified • unknown • not specified • not specified
Study window
Estimated timing pending
Core workflow
Sucrose Self-Administration Task
Primary readouts
- Sucrose self-administration rates
- General learning ability
- Motivation levels
- Comparison with cocaine self-administration rates to determine specificity of neurogenesis effects
Key equipment and reagents
Verified items
0
Direct vendor links
0
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Protocol Steps
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Sucrose Self-Administration Task
Rats perform operant responses to self-administer sucrose as a control measure to assess general learning and motivation
Note: This task was used to determine whether suppression of adult hippocampal neurogenesis affected general learning and motivation, as opposed to drug-specific effects. Sucrose self-administration remained unchanged in irradiated rats, indicating that neurogenesis suppression did not impair general learning or motivation.
View evidence from paper
“This was not a general enhancement of learning, motivation, or locomotion, because sucrose self-administration and locomotor activity were unchanged in irradiated rats”