Source Paper
Lack of striatal-enriched protein tyrosine phosphatase affected the serotonin system, behavior, and brain morphology in mice
Moskaliuk V, Komleva P, Khotskin N, Arefieva A, Shevelev O et al.
Front Psychiatry • 2026
Tail Suspension Test
behavioralMiceC57BL/6-Ptpn5_KO and C57BL/6 (wild type)
Objective: To assess depressive-like behavior in mice by measuring immobility episodes during tail suspension
Protocol Steps
1
Mouse fixation
Attach the mouse by its tail using adhesive tape to a horizontal bar positioned 30 cm above the table surface
View evidence from paper
“A mouse was fixated by the tail with an adhesive tape to a horizontal bar placed 30 cm above the table surface”
2
Recording immobility episodes
During the 6-minute test duration, record immobility episodes when the mouse is passive and hangs motionless
View evidence from paper
“During the 6 min of the test, immobility episodes, during which a mouse was passive and hung motionless, were recorded by the researcher”