Source Paper
Lack of striatal-enriched protein tyrosine phosphatase affected the serotonin system, behavior, and brain morphology in mice
Moskaliuk V, Komleva P, Khotskin N, Arefieva A, Shevelev O et al.
Front Psychiatry • 2026
Tail Suspension Test
Objective: To assess depressive-like behavior in mice by measuring immobility episodes during tail suspension
This is a Tail Suspension Test protocol using Mice as the model organism. The procedure involves 2 procedural steps, 1 equipment items, 2 materials. Extracted from a 2026 paper published in Front Psychiatry.
Model and subjects
Mice • C57BL/6-Ptpn5_KO and C57BL/6 (wild type) • Male • 2-month-old adult • Not specified
Study window
Estimated timing pending
Core workflow
Mouse fixation • Recording immobility episodes
Primary readouts
- Total immobility episodes duration (used to evaluate depressive-like behavior)
Key equipment and reagents
Use this page as an execution guide, then fall back to the source paper whenever you need exact exclusions, dosing details, or assay-specific caveats.
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- Verify the animal model, intervention setup, and collection timepoints against the source paper.
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- Jump to Experimental Context for readouts, data shape, and analysis flow before planning downstream analysis.
Protocol Steps
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Mouse fixation
Attach the mouse by its tail using adhesive tape to a horizontal bar positioned 30 cm above the table surface
View evidence from paper
“A mouse was fixated by the tail with an adhesive tape to a horizontal bar placed 30 cm above the table surface”
Recording immobility episodes
During the 6-minute test duration, record immobility episodes when the mouse is passive and hangs motionless
View evidence from paper
“During the 6 min of the test, immobility episodes, during which a mouse was passive and hung motionless, were recorded by the researcher”