Source Paper
Mateus M Bergamaschi, Regina Helena Costa Queiroz, Marcos Hortes Nisihara Chagas, Danielle Chaves Gomes de Oliveira, Bruno Spinosa De Martinis et al.
Neuropsychopharmacology • 2011
Objective: Measure subjective mood parameters including anxiety, cognitive impairment, discomfort, and alertness at multiple time points during a simulated public speaking test using the Visual Analogue Mood Scale (VAMS)
This is a Visual Analogue Mood Scale protocol using human as the model organism. The procedure involves 8 procedural steps, 3 equipment items, 2 materials. Extracted from a 2011 paper published in Neuropsychopharmacology.
Model and subjects
human • N/A • Not specified • Not specified • Not specified • 48
Study window
~3 hours hands-on
Core workflow
Subject allocation and randomization • Pre-treatment administration • Baseline mood assessment
Primary readouts
Key equipment and reagents
Verified items
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Direct vendor links
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Allocate 24 treatment-naïve SAD patients to receive either CBD (600 mg, n=12) or placebo (n=12) in a double-blind randomized design. Include 12 healthy control subjects who perform SPST without medication.
Note: Double-blind procedure; each volunteer participated in only one experimental session
“A total of 24 never-treated patients with SAD were allocated to receive either CBD (600 mg; n=12) or placebo (placebo; n=12) in a double-blind randomized design”
Administer CBD (600 mg) or placebo to SAD patients 1 hour and 30 minutes before the simulated public speaking test
Note: Double-blind administration
“CBD (600 mg; n=12) or placebo (placebo; n=12) in a double-blind randomized design 1 h and a half before the test”
Administer Visual Analogue Mood Scale (VAMS) at baseline (first of six time points) to measure subjective mood parameters including anxiety, cognitive impairment, discomfort, and alertness
Note: First measurement time point
“Subjective ratings on the Visual Analogue Mood Scale (VAMS) and Negative Self-Statement scale (SSPS-N) and physiological measures (blood pressure, heart rate, and skin conductance) were measured at six different time points during the SPST”
Measure physiological parameters including blood pressure, heart rate, and skin conductance at baseline (first of six time points)
Note: First measurement time point
“physiological measures (blood pressure, heart rate, and skin conductance) were measured at six different time points during the SPST”
Subjects perform the simulated public speaking test (SPST) while mood and physiological measures are collected at five additional time points throughout the test
Note: Measurements taken at six total time points during SPST
“Subjective ratings on the Visual Analogue Mood Scale (VAMS) and Negative Self-Statement scale (SSPS-N) and physiological measures (blood pressure, heart rate, and skin conductance) were measured at six different time points during the SPST”
Administer Visual Analogue Mood Scale at five additional time points during and after the SPST to assess changes in anxiety, cognitive impairment, discomfort, and alertness
Note: Repeated measurement throughout SPST
“Subjective ratings on the Visual Analogue Mood Scale (VAMS) were measured at six different time points during the SPST”
Measure blood pressure, heart rate, and skin conductance at five additional time points during and after the SPST
Note: Repeated measurement throughout SPST
“physiological measures (blood pressure, heart rate, and skin conductance) were measured at six different time points during the SPST”
Administer Negative Self-Statement scale (SSPS-N) at six different time points during the SPST to measure negative self-statements
Note: Repeated measurement throughout SPST
“Subjective ratings on the Visual Analogue Mood Scale (VAMS) and Negative Self-Statement scale (SSPS-N) were measured at six different time points during the SPST”
This section explains what the experiment is doing, which readouts matter, what the data artifacts usually look like, and how the analysis should flow from raw capture to reported result.
Measure subjective mood parameters including anxiety, cognitive impairment, discomfort, and alertness at multiple time points during a simulated public speaking test using the Visual Analogue Mood Scale (VAMS)
Objective
Measure subjective mood parameters including anxiety, cognitive impairment, discomfort, and alertness at multiple time points during a simulated public speaking test using the Visual Analogue Mood Scale (VAMS)
Subjects
From paperhuman • N/A • Not specified • Not specified • Not specified
Sample count
From paper48
Cohort notes
From paper24 treatment-naïve patients with Generalized Social Anxiety Disorder (SAD) allocated to CBD (n=12) or placebo (n=12); 12 healthy control subjects performed SPST without medication
Subject allocation and randomization (Not specified)
Pre-treatment administration (1 hour 30 minutes before SPST)
Baseline mood assessment (Not specified)
Baseline physiological measurements (Not specified)
Visual Analogue Mood Scale (VAMS) scores measuring anxiety
From paperResults were submitted to a repeated-measures analysis of variance
Artifact type
Endpoint measurements summarized by group or timepoint
Comparison focus
Compare endpoint magnitude between groups, timepoints, or both
Visual Analogue Mood Scale (VAMS) scores measuring cognitive impairment
From paperResults were submitted to a repeated-measures analysis of variance
Artifact type
Endpoint measurements summarized by group or timepoint
Comparison focus
Compare endpoint magnitude between groups, timepoints, or both
Visual Analogue Mood Scale (VAMS) scores measuring discomfort
From paperResults were submitted to a repeated-measures analysis of variance
Artifact type
Endpoint measurements summarized by group or timepoint
Comparison focus
Compare endpoint magnitude between groups, timepoints, or both
Visual Analogue Mood Scale (VAMS) scores measuring alertness
From paperResults were submitted to a repeated-measures analysis of variance
Artifact type
Endpoint measurements summarized by group or timepoint
Comparison focus
Compare endpoint magnitude between groups, timepoints, or both
Visual Analogue Mood Scale (VAMS) scores measuring anxiety
From paperRaw artifact
Per-sample or per-animal endpoint measurements collected during the experiment
Processed artifact
Structured table with cleaned measurements ready for comparison
Final reported form
Summary statistics and between-group or across-timepoint comparisons
Visual Analogue Mood Scale (VAMS) scores measuring cognitive impairment
From paperRaw artifact
Per-sample or per-animal endpoint measurements collected during the experiment
Processed artifact
Structured table with cleaned measurements ready for comparison
Final reported form
Summary statistics and between-group or across-timepoint comparisons
Visual Analogue Mood Scale (VAMS) scores measuring discomfort
From paperRaw artifact
Per-sample or per-animal endpoint measurements collected during the experiment
Processed artifact
Structured table with cleaned measurements ready for comparison
Final reported form
Summary statistics and between-group or across-timepoint comparisons
Visual Analogue Mood Scale (VAMS) scores measuring alertness
From paperRaw artifact
Per-sample or per-animal endpoint measurements collected during the experiment
Processed artifact
Structured table with cleaned measurements ready for comparison
Final reported form
Summary statistics and between-group or across-timepoint comparisons
Acquisition
Collect raw experimental outputs with enough metadata to preserve sample identity, condition, and timing.
Preprocessing / cleaning
Results were submitted to a repeated-measures analysis of variance
Scoring or quantification
Quantify the primary readouts for this experiment: Visual Analogue Mood Scale (VAMS) scores measuring anxiety; Visual Analogue Mood Scale (VAMS) scores measuring cognitive impairment; Visual Analogue Mood Scale (VAMS) scores measuring discomfort; Visual Analogue Mood Scale (VAMS) scores measuring alertness.
Statistical comparison
Statistical method not yet structured for this page.
Reporting output
Report representative outputs alongside summary comparisons for Visual Analogue Mood Scale (VAMS) scores measuring anxiety, Visual Analogue Mood Scale (VAMS) scores measuring cognitive impairment, Visual Analogue Mood Scale (VAMS) scores measuring discomfort, Visual Analogue Mood Scale (VAMS) scores measuring alertness.
Source links and direct wording from the methods section for validation and deeper review.
Citation
Mateus M Bergamaschi et al. (2011). Cannabidiol Reduces the Anxiety Induced by Simulated Public Speaking in Treatment-Naïve Social Phobia Patients. Neuropsychopharmacology
Subject allocation and randomization • Protocol step
“A total of 24 never-treated patients with SAD were allocated to receive either CBD (600 mg; n=12) or placebo (placebo; n=12) in a double-blind randomized design”
Pre-treatment administration • Protocol step
“CBD (600 mg; n=12) or placebo (placebo; n=12) in a double-blind randomized design 1 h and a half before the test”
Baseline mood assessment • Protocol step
“Subjective ratings on the Visual Analogue Mood Scale (VAMS) and Negative Self-Statement scale (SSPS-N) and physiological measures (blood pressure, heart rate, and skin conductance) were measured at six different time points during the SPST”
Baseline physiological measurements • Protocol step
“physiological measures (blood pressure, heart rate, and skin conductance) were measured at six different time points during the SPST”
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Current status surfaces were computed from experiment data updated Feb 28, 2026.
Source access
Jump back into the original paper or the methods evidence section when you need exact wording, exclusions, or method-specific caveats.
This protocol has structured steps plus evidence quotes, and is ready for canonical sync.
Steps
8
Evidence Quotes
6
Protocol Items
5
Linked Products
0
Canonical Sync
Pending
What this means
The completeness score reflects how much structured protocol data is present: steps, methods evidence, listed materials, linked products, and paper provenance.
Computed from the current experiment record updated Feb 28, 2026.
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Steps
8
Evidence
6
Specific Products
0/0
Canonical Sync
Pending
What this score means
The verification score reflects evidence coverage, subject detail, paper provenance, step depth, and whether linked products resolve to specific item pages instead of generic searches.
Computed from the current experiment record updated Feb 28, 2026.
A page can have structured steps and still need review when evidence is thin, product links are generic, or canonical protocol coverage is still pending.
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