Source Paper
Reduced fear expression after lesions of the ventral hippocampus
Kirsten G. Kjelstrup, Frode A. Tuvnes, Hill-Aina Steffenach, Robert Murison, Edvard I. Moser et al.
Proceedings of the National Academy of Sciences • 2002
Water Maze
Objective: Assessment of spatial navigation and memory abilities in rats with selective hippocampal lesions
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Protocol Steps
Elevated plus-maze testing
Rats with selective hippocampal lesions were tested in an elevated plus-maze to assess fear-related behavior and avoidance of open arms
Note: Rats with selective hippocampal lesions failed to avoid open arms, indicating reduced fear expression
View evidence from paper
“Rats with selective hippocampal lesions failed to avoid open arms in an elevated plus-maze”
Brightly lit chamber confinement
Rats were confined to a brightly lit chamber to assess neuroendocrine stress responses
Note: Rats with selective hippocampal lesions had decreased neuroendocrine stress responses
View evidence from paper
“decreased neuroendocrine stress responses during confinement to a brightly lit chamber”
Spatial navigation testing
Rats were tested in a water maze to assess spatial navigation and memory abilities
Note: Ventral hippocampal lesions failed to impair spatial navigation performance
View evidence from paper
“Ventral lesions failed to impair contextual fear conditioning or spatial navigation”