Source Paper
The Prefrontal Cortex as a Key Target of the Maladaptive Response to Stress
João J. Cerqueira, François Mailliet, Osborne F. X. Almeida, Thérèse M. Jay, Nuno Sousa
Journal of Neuroscience • 2007
Working Memory Task
Objective: Assessment of working memory performance to evaluate prefrontal cortex-dependent cognitive function in rats exposed to chronic stress
This is a Working Memory Task protocol using rat as the model organism. The procedure involves 1 procedural steps. Extracted from a 2007 paper published in Journal of Neuroscience.
Model and subjects
rat • Not specified • unknown • Not specified • Not specified
Study window
Estimated timing pending
Core workflow
Working Memory Task Assessment
Primary readouts
- Working memory performance
- Behavioral flexibility
- PFC-dependent cognitive function integrity
Key equipment and reagents
Verified items
0
Direct vendor links
0
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Protocol Steps
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Working Memory Task Assessment
Behavioral assessment of working memory performance to evaluate prefrontal cortex-dependent cognitive function
Note: This task measures PFC-dependent working memory function. The text indicates that chronic stress severely disrupts working memory performance.
View evidence from paper
“chronic stress impairs synaptic plasticity by reducing LTP induction in the hippocampal–PFC connection; in addition, it induces selective atrophy within the PFC and severely disrupts working memory”