Acoustic Startle and Prepulse Inhibition Test
Objective: Assessment of startle response and prepulse inhibition to evaluate sensorimotor gating and anxiety in GAT1 knockout mice
This is a Acoustic Startle and Prepulse Inhibition Test protocol using mouse as the model organism. The procedure involves 2 procedural steps, 1 equipment items. Extracted from a 2005 paper published in Journal of Neuroscience.
Model and subjects
mouse • GAT1 knockout (mGAT1 KO) mice • unknown • Not specified • Reduced body weight compared to wild-type (female -10%, male -20%)
Study window
Estimated timing pending
Core workflow
Acoustic Startle Response Assessment • Prepulse Inhibition Assessment
Primary readouts
- Acoustic startle response magnitude
- Prepulse inhibition percentage
- Sensorimotor gating function
- Anxiety-related behavior indicators
Key equipment and reagents
Verified items
0
Direct vendor links
0
Use this page as an execution guide, then fall back to the source paper whenever you need exact exclusions, dosing details, or assay-specific caveats.
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Protocol Steps
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Acoustic Startle Response Assessment
Measure the startle response of GAT1 knockout mice to acoustic stimuli
Note: mGAT1 KO mice showed no difference in acoustic startle response compared to controls
View evidence from paper
“The mGAT1 KO mice display no difference in acoustic startle response but exhibit a deficiency in prepulse inhibition.”
Prepulse Inhibition Assessment
Measure prepulse inhibition (PPI) in GAT1 knockout mice to assess sensorimotor gating
Note: mGAT1 KO mice exhibited a deficiency in prepulse inhibition, suggesting impaired sensorimotor gating
View evidence from paper
“The mGAT1 KO mice display no difference in acoustic startle response but exhibit a deficiency in prepulse inhibition.”