GABA Transporter Deficiency Causes Tremor, Ataxia, Nervousness, and Increased GABA-Induced Tonic Conductance in Cerebellum

Chi-Sung Chiu, Stephen Brickley, Kimmo Jensen, Amber Southwell, Sheri Mckinney et al.

Journal of Neuroscience • 2005

Acoustic Startle and Prepulse Inhibition Test

behavioralmouseGAT1 knockout (mGAT1 KO) mice

Objective: Assessment of startle response and prepulse inhibition to evaluate sensorimotor gating and anxiety in GAT1 knockout mice

Materials & Equipment Checklist

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Gather these items before starting the experiment. Check off items as you prepare.

Acoustic startle apparatus

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Measure the startle response of GAT1 knockout mice to acoustic stimuli

Not specifiedNot specified

Acoustic Startle Chamber

Matches: Acoustic startle apparatus

$7,990View

Note: mGAT1 KO mice showed no difference in acoustic startle response compared to controls

View evidence from paper

“The mGAT1 KO mice display no difference in acoustic startle response but exhibit a deficiency in prepulse inhibition.”

Measure prepulse inhibition (PPI) in GAT1 knockout mice to assess sensorimotor gating

Not specifiedNot specified

Note: mGAT1 KO mice exhibited a deficiency in prepulse inhibition, suggesting impaired sensorimotor gating

View evidence from paper

“The mGAT1 KO mice display no difference in acoustic startle response but exhibit a deficiency in prepulse inhibition.”