Source Paper
Genetic Variant of BDNF (Val66Met) Polymorphism Attenuates Stroke-Induced Angiogenic Responses by Enhancing Anti-Angiogenic Mediator CD36 Expression
Luye Qin, Eunhee Kim, Rajiv Ratan, Francis S. Lee, Sunghee Cho
Journal of Neuroscience • 2011
Post-Stroke Locomotor Function Assessment
Objective: Evaluation of locomotor deficits and functional recovery in mice following stroke, with assessment of how BDNF genetic variants affect post-stroke locomotor function
This is a Post-Stroke Locomotor Function Assessment protocol using mouse as the model organism. The procedure involves 1 procedural steps. Extracted from a 2011 paper published in Journal of Neuroscience.
Model and subjects
mouse • BDNF Met/Met knock-in mice and wild-type controls, with some CD36 knock-out crosses • unknown • Not specified • Not specified
Study window
Estimated timing pending
Core workflow
Assess post-stroke locomotor function
Primary readouts
- Post-stroke locomotor function deficits
- Infarct size
- CNS BDNF levels
- Angiogenesis
Key equipment and reagents
Verified items
0
Direct vendor links
0
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Protocol Steps
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Assess post-stroke locomotor function
Evaluate locomotor deficits in mice following stroke induction
Note: Locomotor function assessment was performed to measure post-stroke deficits
View evidence from paper
“Diminished BDNF levels in BDNF Met/Met mice were associated with greater deficits in post-stroke locomotor functions”