Acoustic Startle Response Test
Objective: Assessment of norepinephrine-dependent startle response in parkin null mice to evaluate the role of locus coeruleus catecholaminergic neurons in acoustic startle
This is a Acoustic Startle Response Test protocol using mouse as the model organism. The procedure involves 1 procedural steps, 1 equipment items. Extracted from a 2004 paper published in Proceedings of the National Academy of Sciences.
Model and subjects
mouse • parkin null mice (targeted deletion of parkin exon 7) • unknown • Not specified • Not specified
Study window
Estimated timing pending
Core workflow
Acoustic Startle Response Assessment
Primary readouts
- Magnitude of acoustic startle response
- Norepinephrine-dependent startle response reduction
Key equipment and reagents
Verified items
0
Direct vendor links
0
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Protocol Steps
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Acoustic Startle Response Assessment
Mice were tested for acoustic startle response to evaluate norepinephrine-dependent startle function
Note: The test specifically measures norepinephrine-dependent startle response, which is reduced in parkin null mice
View evidence from paper
“dramatic reduction of the norepinephrine-dependent startle response”