Deficiency in the Inhibitory Serine-Phosphorylation of Glycogen Synthase Kinase-3 Increases Sensitivity to Mood Disturbances

Abigail Polter, Eléonore Beurel, Sufen Yang, Rakesha Garner, Ling Song et al.

Neuropsychopharmacology • 2010

Amphetamine-Induced Hyperactivity Test

behavioralmouseGSK3 α/β 21A/21A/9A/9A knockin mice and wild-type controls

Objective: Measurement of increased susceptibility to amphetamine-induced hyperactivity in GSK3 knockin mice compared to wild-type controls

Behavioral measurement of hyperactivity response to amphetamine administration in GSK3 knockin mice versus wild-type controls

Not specifiedNot specified

Note: GSK3 knockin mice displayed increased susceptibility to amphetamine-induced hyperactivity compared to controls

View evidence from paper

“GSK3 knockin mice displayed increased susceptibility to amphetamine-induced hyperactivity and to stress-induced depressive-like behaviors”