Apomorphine-Induced Locomotor and Stereotyped Behavior Test
behavioralmouseNot specified in provided text
Objective: Assessment of locomotor and stereotyped behavioral responses following acute apomorphine treatment in offspring exposed to prenatal immune challenge
Materials & Equipment Checklist
2 items
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Protocol Steps
1
Prenatal immune challenge administration
Pregnant dams receive intravenous injection of Poly-I:C on gestation day 17
Not specifiedNot specified
Note: This is the prenatal treatment; the apomorphine test is conducted on offspring
View evidence from paper
“prenatal exposure to the viral mimic polyriboinosinic-polyribocytidilic acid (Poly-I:C; 5 mg/kg, i.v.) on gestation day (GD) 17”
2
Acute apomorphine treatment and behavioral assessment
Offspring receive acute apomorphine treatment and locomotor and stereotyped behavioral responses are assessed
Not specifiedNot specified
Note: Assessment conducted in both male and female offspring
View evidence from paper
“alterations in the locomotor and stereotyped behavioral responses to acute apomorphine (APO) treatment in both male and female offspring”