Apomorphine-Induced Locomotor and Stereotyped Behavior Test
Objective: Assessment of locomotor and stereotyped behavioral responses following acute apomorphine treatment in offspring exposed to prenatal immune challenge
This is a Apomorphine-Induced Locomotor and Stereotyped Behavior Test protocol using mouse as the model organism. The procedure involves 2 procedural steps, 2 materials. Extracted from a 2010 paper published in Neuropsychopharmacology.
Model and subjects
mouse • Not specified in provided text • both • Not specified in provided text • Not specified in provided text
Study window
Estimated timing pending
Core workflow
Prenatal immune challenge administration • Acute apomorphine treatment and behavioral assessment
Primary readouts
- Locomotor behavioral responses to apomorphine
- Stereotyped behavioral responses to apomorphine
- Social interaction deficits
- Anhedonic behavior
Key equipment and reagents
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Protocol Steps
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Prenatal immune challenge administration
Pregnant dams receive intravenous injection of Poly-I:C on gestation day 17
Note: This is the prenatal treatment; the apomorphine test is conducted on offspring
View evidence from paper
“prenatal exposure to the viral mimic polyriboinosinic-polyribocytidilic acid (Poly-I:C; 5 mg/kg, i.v.) on gestation day (GD) 17”
Acute apomorphine treatment and behavioral assessment
Offspring receive acute apomorphine treatment and locomotor and stereotyped behavioral responses are assessed
Note: Assessment conducted in both male and female offspring
View evidence from paper
“alterations in the locomotor and stereotyped behavioral responses to acute apomorphine (APO) treatment in both male and female offspring”