Source Paper
Atrophin-1 antisense oligonucleotide provides robust protection from pathology in a fully humanized DRPLA model
Smith VL, Gidi BZ, Bragg RM, Cantle JP, Ben-Varon A et al.
Mol Ther Nucleic Acids • 2025
Balance Beam
Objective: To assess motor coordination and balance ability in mice using a balance beam task
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Protocol Steps
Setup apparatus
Set up metal rod at tapered angle with dark box at one end and 60-watt lamp at the other end
View evidence from paper
“metal rod set up at a tapered angle with a dark box at one end and 60-watt lamp on the other”
Prepare dark box
Place nestling and bedding from the mouse's home cage in the dark box
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“The dark box had nestling and bedding from the mouse's home cage”
Training day 1
Train mice with three trials on both the 12 mm and 6 mm diameter rods
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“Mice were trained for two days with three trials on both rods”
Training day 2
Continue training mice with three trials on both the 12 mm and 6 mm diameter rods
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“Mice were trained for two days with three trials on both rods”
Testing day
Test mice on the third day with three trials on the 6 mm diameter rod only
View evidence from paper
“The mice were tested on the third day with three trials on the 6 mm rod”
Clean between subjects
Clean the dark box and rod with 70% ethanol between different cages of mice
View evidence from paper
“The dark box and rod were cleaned with 70% ethanol between cages”