Source Paper
Atrophin-1 antisense oligonucleotide provides robust protection from pathology in a fully humanized DRPLA model
Smith VL, Gidi BZ, Bragg RM, Cantle JP, Ben-Varon A et al.
Mol Ther Nucleic Acids • 2025
Balance Beam Test
Objective: Test motor coordination and balance using a tapered balance beam apparatus
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Protocol Steps
Equipment setup
Set up metal rod at tapered angle with dark box at one end containing home cage bedding and 60-watt lamp at other end
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“set up at a tapered angle with a dark box at one end and 60-watt lamp on the other”
Training phase
Train mice for two days with three trials on both 12 mm and 6 mm diameter rods
View evidence from paper
“Mice were trained for two days with three trials on both rods”
Testing phase
Test mice on third day with three trials specifically on the 6 mm diameter rod
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“The mice were tested on the third day with three trials on the 6 mm rod”
Cleaning between subjects
Clean dark box and rod with 70% ethanol between different cages of mice
View evidence from paper
“The dark box and rod were cleaned with 70% ethanol between cages”