Source Paper
Atrophin-1 antisense oligonucleotide provides robust protection from pathology in a fully humanized DRPLA model
Smith VL, Gidi BZ, Bragg RM, Cantle JP, Ben-Varon A et al.
Mol Ther Nucleic Acids • 2025
Balance Beam Test
Objective: Test motor coordination and balance using a tapered balance beam apparatus
This is a Balance Beam Test protocol using Mouse as the model organism. The procedure involves 4 procedural steps, 1 equipment items, 4 materials. Extracted from a 2025 paper published in Mol Ther Nucleic Acids.
Model and subjects
Mouse • Not specified • Male and female • 6 to 7 weeks • Not specified
Study window
Estimated timing pending
Core workflow
Equipment setup • Training phase • Testing phase
Primary readouts
- Motor coordination and balance performance on 6 mm diameter rod
Key equipment and reagents
Use this page as an execution guide, then fall back to the source paper whenever you need exact exclusions, dosing details, or assay-specific caveats.
Confirm first
- Verify the animal model, intervention setup, and collection timepoints against the source paper.
- Check that every direct vendor link matches the exact specification your lab plans to run.
Use the page like this
- Work through the protocol steps in order and use the inline vendor chips only when you need to source or verify an item.
- Jump to Experimental Context for readouts, data shape, and analysis flow before planning downstream analysis.
Protocol Steps
Start here. The step list is optimized for running the experiment, with direct vendor links available inline when you need to source a cited item.
Equipment setup
Set up metal rod at tapered angle with dark box at one end containing home cage bedding and 60-watt lamp at other end
View evidence from paper
“set up at a tapered angle with a dark box at one end and 60-watt lamp on the other”
Training phase
Train mice for two days with three trials on both 12 mm and 6 mm diameter rods
View evidence from paper
“Mice were trained for two days with three trials on both rods”
Testing phase
Test mice on third day with three trials specifically on the 6 mm diameter rod
View evidence from paper
“The mice were tested on the third day with three trials on the 6 mm rod”
Cleaning between subjects
Clean dark box and rod with 70% ethanol between different cages of mice
View evidence from paper
“The dark box and rod were cleaned with 70% ethanol between cages”