Barnes Maze Test
Objective: Evaluate spatial learning and memory deficits in mice after traumatic brain injury using the Barnes maze test
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Equipment2
Materials2
Software1
Not specified • Not specified
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Estimated: $5,100.00
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Protocol Steps
Traumatic Brain Injury or Sham Surgery
Mice underwent either moderate to severe TBI produced by controlled cortical impact or sham surgery
Note: Baseline procedure performed before treatment initiation
View evidence from paper
“a moderate to severe TBI, produced by a controlled cortical impact”
Treatment Initiation
Three days after TBI or sham surgery, mice were assigned to treatment groups
Note: Treatment began 3 days after initial surgery
View evidence from paper
“Three days after TBI or sham surgery, mice were treated with fluoxetine (10 mg/kg/d) or vehicle for 4 weeks”
Drug Administration
Fluoxetine or vehicle administered to mice
Note: Fluoxetine group received 10 mg/kg/d; control group received vehicle
View evidence from paper
“mice were treated with fluoxetine (10 mg/kg/d) or vehicle for 4 weeks”
Gait Function Assessment
Gait function evaluated using CatWalk-assisted gait test
Note: Performed to assess locomotor function
View evidence from paper
“gait function and spatial learning and memory were assessed by the CatWalk-assisted gait test and Barnes maze test, respectively”
Spatial Learning and Memory Assessment
Spatial learning and memory evaluated using Barnes maze test
Note: Primary behavioral outcome measure for memory assessment
View evidence from paper
“spatial learning and memory were assessed by the CatWalk-assisted gait test and Barnes maze test, respectively”