Role of the Dorsal Medial Habenula in the Regulation of Voluntary Activity, Motor Function, Hedonic State, and Primary Reinforcement

Yun-Wei A. Hsu, Si D. Wang, Shirong Wang, Glenn Morton, Hatim A. Zariwala et al.

Journal of Neuroscience • 2014

DOI PMC

Basal Locomotion Assessment

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Objective: Measurement of baseline locomotor activity levels in mice with dorsal medial habenula lesions to assess basal locomotion

Protocol Steps

Basal Locomotion Assessment

Measurement of baseline locomotor activity levels in mice with dorsal medial habenula lesions

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Note: Mice with dMHb lesions show only minor abnormalities in gait and balance and exhibit normal levels of basal locomotion

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“Mice with dMHb lesions perform poorly in motivation-based locomotor behaviors, such as voluntary wheel running and the accelerating rotarod, but show only minor abnormalities in gait and balance and exhibit normal levels of basal locomotion”