Source Paper
Reduction in Mitochondrial Superoxide Dismutase Modulates Alzheimer's Disease-Like Pathology and Accelerates the Onset of Behavioral Changes in Human Amyloid Precursor Protein Transgenic Mice
Luke Esposito, Jacob Raber, Lisa Kekonius, Fengrong Yan, Giu-Qiu Yu et al.
Journal of Neuroscience • 2006
Behavioral Assessment in hAPP Transgenic Mice
Objective: Assessment of behavioral alterations and onset of behavioral changes in hAPP transgenic mice with reduced Sod2 activity, including sensorimotor gating deficits
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Protocol Steps
Behavioral assessment in hAPP transgenic mice
Conduct behavioral testing to assess alterations and onset of behavioral changes in hAPP transgenic mice with reduced Sod2 activity compared to wild-type controls
Note: Testing performed on hAPP mice with Sod2 +/- genotype versus Sod2 +/+ controls
View evidence from paper
“Assessment of behavioral alterations and onset of behavioral changes in hAPP transgenic mice”
Prepulse inhibition of acoustic startle testing
Measure prepulse inhibition of acoustic startle as an indicator of sensorimotor gating deficits in hAPP mice with reduced Sod2 activity
Note: This measure was accelerated in onset in hAPP mice with reduced Sod2 activity
View evidence from paper
“deficits in prepulse inhibition of acoustic startle, a measure of sensorimotor gating”