Behavioral Memory Testing
behavioralmouse5xfAD
Objective: To assess cognitive function and memory improvements in 5xfAD mice through contextual memory testing following microglial elimination
Materials & Equipment Checklist
1 item
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Materials1
Not explicitly stated • Not applicable • Not mentioned • Not mentioned
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Protocol Steps
1
Animal treatment with CSF1R inhibitor
Ten-month-old 5xfAD mice were treated with a selective CSF1R inhibitor
1 monthNot specified
Note: Treatment resulted in elimination of approximately 80% of microglia
View evidence from paper
“Ten-month-old 5xfAD mice were treated with a selective CSF1R inhibitor for 1 month, resulting in the elimination of ∼80% of microglia”
2
Behavioral testing for contextual memory
Behavioral testing was performed to assess contextual memory in treated mice
Not specifiedNot specified
Note: Testing revealed improvements in contextual memory following microglial elimination
View evidence from paper
“behavioural testing revealed improvements in contextual memory”