Behavioral Memory Testing
Objective: To assess cognitive function and memory improvements in 5xfAD mice through contextual memory testing following microglial elimination
This is a Behavioral Memory Testing protocol using mouse as the model organism. The procedure involves 2 procedural steps, 1 materials. Extracted from a 2016 paper published in Brain.
Model and subjects
mouse • 5xfAD • unknown • Ten-month-old • Not specified
Study window
Estimated timing pending
Core workflow
Animal treatment with CSF1R inhibitor • Behavioral testing for contextual memory
Primary readouts
- Contextual memory performance
- Amyloid-β levels
- Plaque load
- Dendritic spine density
Key equipment and reagents
Verified items
0
Direct vendor links
0
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Protocol Steps
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Animal treatment with CSF1R inhibitor
Ten-month-old 5xfAD mice were treated with a selective CSF1R inhibitor
Note: Treatment resulted in elimination of approximately 80% of microglia
View evidence from paper
“Ten-month-old 5xfAD mice were treated with a selective CSF1R inhibitor for 1 month, resulting in the elimination of ∼80% of microglia”
Behavioral testing for contextual memory
Behavioral testing was performed to assess contextual memory in treated mice
Note: Testing revealed improvements in contextual memory following microglial elimination
View evidence from paper
“behavioural testing revealed improvements in contextual memory”