Behavioral Stress Responsivity Testing
Objective: Assessment of maladaptive behavioral stress responsivity and anhedonia in offspring exposed to prenatal stress at different gestational periods (early, mid, and late gestation)
This is a Behavioral Stress Responsivity Testing protocol using mouse as the model organism. The procedure involves 4 procedural steps. Extracted from a 2008 paper published in Journal of Neuroscience.
Model and subjects
mouse • Not specified in provided text • unknown • Not specified in provided text • Not specified in provided text
Study window
Estimated timing pending
Core workflow
Prenatal Stress Exposure • Behavioral Stress Responsivity Testing • Anhedonia Assessment
Primary readouts
- Maladaptive behavioral stress responsivity
- Anhedonia
- Sensitivity to selective serotonin reuptake inhibitor treatment
- Central corticotropin-releasing factor (CRF) expression
Key equipment and reagents
Verified items
0
Direct vendor links
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Protocol Steps
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Prenatal Stress Exposure
Pregnant dams exposed to stress during early, mid, or late gestation periods
Note: Three different gestational time windows examined to determine critical period for fetal antecedents inducing disease predisposition
View evidence from paper
“examined behavioral responses in offspring exposed to stress during early, mid, and late gestation”
Behavioral Stress Responsivity Testing
Assessment of maladaptive behavioral stress responsivity in offspring
Note: Male offspring exposed to stress early in gestation displayed maladaptive behavioral stress responsivity
View evidence from paper
“male offspring exposed to stress early in gestation displayed maladaptive behavioral stress responsivity”
Anhedonia Assessment
Evaluation of anhedonia in offspring
Note: Anhedonia was measured as an outcome in offspring exposed to early prenatal stress
View evidence from paper
“male offspring exposed to stress early in gestation displayed maladaptive behavioral stress responsivity, anhedonia”
SSRI Treatment Sensitivity Testing
Assessment of sensitivity to selective serotonin reuptake inhibitor treatment
Note: Increased sensitivity to SSRI treatment observed in male offspring exposed to early prenatal stress
View evidence from paper
“increased sensitivity to selective serotonin reuptake inhibitor treatment”