Source Paper
Alzheimer's Disease-Like Tau Neuropathology Leads to Memory Deficits and Loss of Functional Synapses in a Novel Mutated Tau Transgenic Mouse without Any Motor Deficits
Katharina Schindowski, Alexis Bretteville, Karelle Leroy, Séverine Bégard, Jean-Pierre Brion et al.
American Journal Of Pathology • 2006
Behavioral Testing - Anxiety and Learning
Objective: Assessment of increased anxiety, delayed learning from 3 months, and reduced spatial memory at 10 months in THY-Tau22 transgenic mice expressing human mutated tau protein
This is a Behavioral Testing - Anxiety and Learning protocol using mouse as the model organism. The procedure involves 4 procedural steps. Extracted from a 2006 paper published in American Journal Of Pathology.
Model and subjects
mouse • THY-Tau22 transgenic • unknown • 3 months and 10 months • Not specified
Study window
Estimated timing pending
Core workflow
Anxiety Assessment • Learning Assessment • Spatial Memory Assessment
Primary readouts
- Increased anxiety levels
- Delayed learning performance
- Reduced spatial memory
- Motor activity and motor deficits
Key equipment and reagents
Verified items
0
Direct vendor links
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Protocol Steps
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Anxiety Assessment
Behavioral testing to assess increased anxiety in THY-Tau22 transgenic mice
Note: Testing performed at 3 months of age as part of initial behavioral characterization
View evidence from paper
“These mice also display deficits in hippocampal synaptic transmission and impaired behavior characterized by increased anxiety”
Learning Assessment
Behavioral testing to assess delayed learning in THY-Tau22 transgenic mice
Note: Testing performed starting at 3 months of age
View evidence from paper
“delayed learning from 3 months, and reduced spatial memory at 10 months”
Spatial Memory Assessment
Behavioral testing to assess reduced spatial memory in THY-Tau22 transgenic mice
Note: Testing performed at 10 months of age
View evidence from paper
“reduced spatial memory at 10 months”
Motor Function Assessment
Assessment of motor deficits and motor activity across all ages investigated
Note: No signs of motor deficits or changes in motor activity detected at any age
View evidence from paper
“There are no signs of motor deficits or changes in motor activity at any age investigated”