Source Paper
Alzheimer's Disease-Like Tau Neuropathology Leads to Memory Deficits and Loss of Functional Synapses in a Novel Mutated Tau Transgenic Mouse without Any Motor Deficits
Katharina Schindowski, Alexis Bretteville, Karelle Leroy, Séverine Bégard, Jean-Pierre Brion et al.
American Journal Of Pathology • 2006
Behavioral Testing - Anxiety and Learning
Objective: Assessment of increased anxiety, delayed learning from 3 months, and reduced spatial memory at 10 months in THY-Tau22 transgenic mice expressing human mutated tau protein
Protocol Steps
Anxiety Assessment
Behavioral testing to assess increased anxiety in THY-Tau22 transgenic mice
Note: Testing performed at 3 months of age as part of initial behavioral characterization
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“These mice also display deficits in hippocampal synaptic transmission and impaired behavior characterized by increased anxiety”
Learning Assessment
Behavioral testing to assess delayed learning in THY-Tau22 transgenic mice
Note: Testing performed starting at 3 months of age
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“delayed learning from 3 months, and reduced spatial memory at 10 months”
Spatial Memory Assessment
Behavioral testing to assess reduced spatial memory in THY-Tau22 transgenic mice
Note: Testing performed at 10 months of age
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“reduced spatial memory at 10 months”
Motor Function Assessment
Assessment of motor deficits and motor activity across all ages investigated
Note: No signs of motor deficits or changes in motor activity detected at any age
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“There are no signs of motor deficits or changes in motor activity at any age investigated”