Experiments/Behavioral Testing

Source Paper

Nonresonant powering of injectable nanoelectrodes enables wireless deep brain stimulation in freely moving mice

K. L. Kozielski, A. Jahanshahi, H. B. Gilbert, Y. Yu, Ö. Erin et al.

Science Advances • 2021

DOI PMC

Behavioral Testing

behavioralmouse

Objective: Assess the potential of MENPs to wirelessly modulate neuronal activity via magnetoelectric response to applied magnetic field and measure effects on mouse behavior

This is a Behavioral Testing protocol using mouse as the model organism. The procedure involves 5 procedural steps. Extracted from a 2021 paper published in Science Advances.

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Overview Experimental Context Protocol Vendor Comparison Materials Checklist Evidence / Verification Related Experiments

Replication Essentials

Model and subjects

mouse

Study window

Estimated timing pending

Core workflow

Magnetic field application to nanoparticles • Measure nanoparticle output electric signaling • Assess neuronal modulation in culture

Primary readouts

Output electric signaling from nanoparticles
Neuronal cell activity modulation in culture
Brain activity modulation in mice
Mouse behavioral changes

Key equipment and reagents

Procurement Snapshot

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Before You Start

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Protocol Steps

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Magnetic field application to nanoparticles

Apply magnetic field to MENPs and control nanoparticles. Experimental design includes application of large DC magnetic field overlaid with smaller AC magnetic field for magnetoelectric effect measurement, with AC and DC magnetic field application alone used as experimental controls.

Note: Magnetoelectric effect expected only when applying large DC magnetic field overlaid with smaller AC magnetic field

View evidence from paper

“applying a magnetic field to the MENPs (and control nanoparticles) and measuring (i) their output electric signaling, (ii) their ability to modulate neuronal cell activity in culture, (iii) their ability to modulate brain activity in mice, and (iv) the effect of this modulation on mouse behavior”

Measure nanoparticle output electric signaling

Measure the output electric signaling from MENPs in response to applied magnetic field

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“measuring (i) their output electric signaling”

Assess neuronal modulation in culture

Evaluate the ability of MENPs to modulate neuronal cell activity in culture

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“their ability to modulate neuronal cell activity in culture”

Assess brain activity modulation in mice

Evaluate the ability of MENPs to modulate brain activity in mice

View evidence from paper

“their ability to modulate brain activity in mice”