Source Paper
Environmental Enrichment Rescues Protein Deficits in a Mouse Model of Huntington's Disease, Indicating a Possible Disease Mechanism
Tara L. Spires, Helen E. Grote, Neelash K. Varshney, Patricia M. Cordery, Anton van Dellen et al.
Journal of Neuroscience • 2004
Body Weight Measurement
Objective: Monitor body weight changes in HD transgenic mice to assess the effects of environmental enrichment on HD-induced weight loss
Gather these items before starting the experiment. Check off items as you prepare.
Equipment1
not specified • not specified • not specified • not mentioned
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Protocol Steps
Establish experimental groups
Divide R6/1 transgenic mice into enriched and non-enriched groups for comparison
Note: Study examines effects of environmental enrichment on HD-induced weight loss
View evidence from paper
“enrichment ameliorates motor symptoms and prevents loss of body weight induced by the HD transgene”
Measure body weight at 5 months of age
Weigh mice at 5 months of age to assess body weight changes between enriched and non-enriched HD transgenic mice
Note: Body weight measurement is used as an outcome measure to evaluate enrichment effects
View evidence from paper
“at 5 months of age, enrichment ameliorates motor symptoms and prevents loss of body weight induced by the HD transgene”