CatWalk-Assisted Gait Test
Objective: Assessment of locomotor function and gait parameters in mice after traumatic brain injury (TBI) or sham surgery treated with fluoxetine or vehicle
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Equipment1
Noldus • Not specified • Not specified • Not specified
Materials2
Software1
Noldus • Not specified
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Protocol Steps
Surgical intervention
Mice underwent either controlled cortical impact (TBI) or sham surgery
Note: Moderate to severe TBI was produced by controlled cortical impact
View evidence from paper
“a moderate to severe TBI, produced by a controlled cortical impact”
Treatment initiation
Three days after TBI or sham surgery, mice were treated with fluoxetine or vehicle
Note: Treatment began 3 days post-surgery and continued for 4 weeks
View evidence from paper
“Three days after TBI or sham surgery, mice were treated with fluoxetine (10 mg/kg/d) or vehicle for 4 weeks”
CatWalk gait assessment
Gait function was assessed using the CatWalk-assisted gait test to evaluate locomotor function and gait parameters
Note: Assessment performed to determine if fluoxetine improves neurological outcomes after TBI
View evidence from paper
“gait function and spatial learning and memory were assessed by the CatWalk-assisted gait test and Barnes maze test, respectively”