Challenging Beam Test
Objective: Assessment of motor performance and coordination on a challenging beam as part of a sensorimotor test battery sensitive to nigrostriatal dopaminergic system alterations
This is a Challenging Beam Test protocol using mouse as the model organism. The procedure involves 2 procedural steps, 1 equipment items. Extracted from a 2004 paper published in Journal of Neuroscience.
Model and subjects
mouse • Wild-type and ASO (alpha-synuclein overexpressing) • male • Tested every 2 months for 8 months, starting at unspecified baseline age
Study window
Estimated timing pending
Core workflow
Baseline and longitudinal testing schedule • Motor performance and coordination assessment
Primary readouts
- Motor performance on challenging beam
- Coordination on challenging beam
- Progressive changes in motor performance with age
- Comparison between wild-type and ASO transgenic mice
Key equipment and reagents
Verified items
0
Direct vendor links
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Protocol Steps
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Baseline and longitudinal testing schedule
Male wild-type and ASO mice were tested on the challenging beam as part of a battery of sensorimotor tests
Note: Testing was part of a comprehensive sensorimotor assessment battery that also included inverted grid, pole, adhesive removal test, cylinder test, gait analysis, and fine motor skills assessment
View evidence from paper
“Male wild-type and ASO mice were tested every 2 months for 8 months for motor performance and coordination on a challenging beam”
Motor performance and coordination assessment
Mice were assessed for motor performance and coordination on the challenging beam apparatus
Note: This test is sensitive to alterations in the nigrostriatal dopaminergic system
View evidence from paper
“examined the motor deficits in ASO mice with a battery of sensorimotor tests that are sensitive to alterations in the nigrostriatal dopaminergic system”