Chronic GHS-R Antagonist Treatment in Obese Mice
Objective: To examine the effects of GHS-R antagonist repeated administration on body weight gain and glycaemic control in ob/ob obese mice
This is a Chronic GHS-R Antagonist Treatment in Obese Mice protocol using mouse as the model organism. The procedure involves 3 procedural steps. Extracted from a 2003 paper published in Gut.
Model and subjects
mouse • ob/ob obese mice • unknown • Not specified • Not specified
Study window
Estimated timing pending
Core workflow
GHS-R Antagonist Administration • Body Weight Measurement • Glycaemic Control Assessment
Primary readouts
- Body weight gain
- Glycaemic control (glucose levels)
- Fat mass
- Insulin levels
Key equipment and reagents
Verified items
0
Direct vendor links
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Protocol Steps
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GHS-R Antagonist Administration
Repeated administration of GHS-R antagonist was continued for six days in ob/ob obese mice
Note: This is a chronic treatment protocol with repeated dosing
View evidence from paper
“Repeated administration of GHS-R antagonist was continued for six days in ob/ob obese mice”
Body Weight Measurement
Body weight gain was measured throughout the treatment period
Note: Body weight gain was assessed as an outcome measure
View evidence from paper
“Body weight, fat mass, glucose, insulin, and gene expression of leptin, adiponectin, and resistin in white adipose tissue (WAT) were measured”
Glycaemic Control Assessment
Glucose levels were measured to assess glycaemic control
Note: Glycaemic control was improved by GHS-R antagonist treatment
View evidence from paper
“Repeated administration of GHS-R antagonist decreased body weight gain and improved glycaemic control in ob/ob obese mice”