Antagonism of ghrelin receptor reduces food intake and body weight gain in mice

A Asakawa, A Inui, T Kaga, G Katsuura, M Fujimiya et al.

Gut • 2003

Chronic GHS-R Antagonist Treatment in Obese Mice

behavioralmouseob/ob obese mice

Objective: To examine the effects of GHS-R antagonist repeated administration on body weight gain and glycaemic control in ob/ob obese mice

Repeated administration of GHS-R antagonist was continued for six days in ob/ob obese mice

Six daysNot specified

Note: This is a chronic treatment protocol with repeated dosing

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“Repeated administration of GHS-R antagonist was continued for six days in ob/ob obese mice”

Body weight gain was measured throughout the treatment period

Measured over six-day treatment periodNot specified

Note: Body weight gain was assessed as an outcome measure

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“Body weight, fat mass, glucose, insulin, and gene expression of leptin, adiponectin, and resistin in white adipose tissue (WAT) were measured”

Glucose levels were measured to assess glycaemic control

Measured over six-day treatment periodNot specified

Note: Glycaemic control was improved by GHS-R antagonist treatment

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“Repeated administration of GHS-R antagonist decreased body weight gain and improved glycaemic control in ob/ob obese mice”