Classical Conditioning
Objective: Evaluation of classical conditioning abilities in mice to assess associative learning and determine the role of SIRT1 in cognitive function
This is a Classical Conditioning protocol using mouse as the model organism. The procedure involves 2 procedural steps. Extracted from a 2010 paper published in Journal of Neuroscience.
Model and subjects
mouse • Not specified in provided text • unknown • Not specified in provided text • Not specified in provided text
Study window
Estimated timing pending
Core workflow
Classical Conditioning Assessment • Evaluation of Cognitive Deficits
Primary readouts
- Classical conditioning performance
- Associative learning ability
- Immediate memory
- Spatial learning
Key equipment and reagents
Verified items
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Direct vendor links
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Protocol Steps
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Classical Conditioning Assessment
Mice were evaluated for classical conditioning abilities as part of a behavioral paradigm to assess associative learning
Note: Classical conditioning was one of several behavioral tests used to evaluate cognitive function in SIRT1-deficient and control mice
View evidence from paper
“Using a combination of behavioral and electrophysiological paradigms, we analyzed the effects of SIRT1 deficiency and overexpression on mouse learning and memory”
Evaluation of Cognitive Deficits
Assessment of cognitive abilities including immediate memory, classical conditioning, and spatial learning in SIRT1 knock-out mice compared to controls
Note: The absence of SIRT1 impaired cognitive abilities
View evidence from paper
“We demonstrated that the absence of SIRT1 impaired cognitive abilities, including immediate memory, classical conditioning, and spatial learning”