Classical Conditioning
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Objective: Evaluation of classical conditioning abilities in mice to assess associative learning and determine the role of SIRT1 in cognitive function
Protocol Steps
1
Classical Conditioning Assessment
Mice were evaluated for classical conditioning abilities as part of a behavioral paradigm to assess associative learning
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Note: Classical conditioning was one of several behavioral tests used to evaluate cognitive function in SIRT1-deficient and control mice
View evidence from paper
“Using a combination of behavioral and electrophysiological paradigms, we analyzed the effects of SIRT1 deficiency and overexpression on mouse learning and memory”
2
Evaluation of Cognitive Deficits
Assessment of cognitive abilities including immediate memory, classical conditioning, and spatial learning in SIRT1 knock-out mice compared to controls
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Note: The absence of SIRT1 impaired cognitive abilities
View evidence from paper
“We demonstrated that the absence of SIRT1 impaired cognitive abilities, including immediate memory, classical conditioning, and spatial learning”