Cocaine-Induced Place Preference
Objective: Assessment of conditioned place preference for cocaine to measure rewarding properties of the drug and evaluate cocaine-induced place preference in mice lacking dopamine D2 autoreceptors
This is a Cocaine-Induced Place Preference protocol using mouse as the model organism. The procedure involves 1 procedural steps. Extracted from a 2011 paper published in Nature Neuroscience.
Model and subjects
mouse • autoDrd2KO mice (Drd2 loxP/loxP; Dat +/IRES-cre) and controls • unknown • Not specified • Not specified
Study window
Estimated timing pending
Core workflow
Cocaine-Induced Place Preference Assessment
Primary readouts
- Place preference for cocaine
- Rewarding properties of cocaine
- Comparison between autoDrd2KO mice and wild-type controls
Key equipment and reagents
Verified items
0
Direct vendor links
0
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Protocol Steps
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Cocaine-Induced Place Preference Assessment
Mice were assessed for place preference for cocaine to measure the rewarding properties of the drug
Note: The experiment measured increased place preference for cocaine in autoDrd2KO mice compared to controls
View evidence from paper
“The mice also exhibited increased place preference for cocaine and enhanced motivation for food reward”