Cocaine supersensitivity and enhanced motivation for reward in mice lacking dopamine D2 autoreceptors

Estefanía P Bello, Yolanda Mateo, Diego M Gelman, Daniela Noaín, Jung H Shin et al.

Nature Neuroscience • 2011

DOI PMC

Cocaine-Induced Place Preference

behavioralmouseautoDrd2KO mice (Drd2 loxP/loxP; Dat +/IRES-cre) and controls

Objective: Assessment of conditioned place preference for cocaine to measure rewarding properties of the drug and evaluate cocaine-induced place preference in mice lacking dopamine D2 autoreceptors

Protocol Steps

Cocaine-Induced Place Preference Assessment

Mice were assessed for place preference for cocaine to measure the rewarding properties of the drug

Not specifiedNot specified

Note: The experiment measured increased place preference for cocaine in autoDrd2KO mice compared to controls

View evidence from paper

“The mice also exhibited increased place preference for cocaine and enhanced motivation for food reward”