Cognitive Function Testing
Objective: Assessment of cognitive performance and memory deficits in BACE1 null and transgenic mice, including hippocampal synaptic plasticity and emotional function tests
This is a Cognitive Function Testing protocol using mouse as the model organism. The procedure involves 3 procedural steps. Extracted from a 2005 paper published in Journal of Neuroscience.
Model and subjects
mouse • BACE1 null mice, APPswe;PS1 ΔE9 transgenic mice, and wild-type controls • unknown • Not specified in provided text • Not specified in provided text
Study window
Estimated timing pending
Core workflow
Cognitive Function Testing • Emotional Function Testing • Hippocampal Synaptic Plasticity Assessment
Primary readouts
- Cognitive performance scores
- Memory deficits
- Emotional alterations
- Hippocampal synaptic plasticity changes
Key equipment and reagents
Verified items
0
Direct vendor links
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Protocol Steps
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Cognitive Function Testing
Performance on tests of cognition was assessed in BACE1 null mice and transgenic controls
Note: Memory deficits were evaluated; specific test types not detailed in provided excerpt
View evidence from paper
“BACE1 null mice manifest alterations in hippocampal synaptic plasticity as well as in performance on tests of cognition and emotion”
Emotional Function Testing
Emotional alterations were assessed in BACE1 null mice and transgenic controls
Note: Emotional alterations in BACE1 null mice were not prevented by coexpressing APPswe;PS1 ΔE9 transgenes
View evidence from paper
“memory deficits but not emotional alterations in BACE1 –/– mice are prevented by coexpressing APPswe;PS1 ΔE9 transgenes”
Hippocampal Synaptic Plasticity Assessment
Alterations in hippocampal synaptic plasticity were measured in BACE1 null mice
Note: Specific methodology for synaptic plasticity measurement not detailed in provided excerpt
View evidence from paper
“BACE1 null mice manifest alterations in hippocampal synaptic plasticity as well as in performance on tests of cognition and emotion”