BACE1, a Major Determinant of Selective Vulnerability of the Brain to Amyloid-β Amyloidogenesis, is Essential for Cognitive, Emotional, and Synaptic Functions

Fiona M. Laird, Huaibin Cai, Alena V. Savonenko, Mohamed H. Farah, Kaiwen He et al.

Journal of Neuroscience • 2005

DOI PMC

Cognitive Function Testing

behavioralmouseBACE1 null mice, APPswe;PS1 ΔE9 transgenic mice, and wild-type controls

Objective: Assessment of cognitive performance and memory deficits in BACE1 null and transgenic mice, including hippocampal synaptic plasticity and emotional function tests

Protocol Steps

Cognitive Function Testing

Performance on tests of cognition was assessed in BACE1 null mice and transgenic controls

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Note: Memory deficits were evaluated; specific test types not detailed in provided excerpt

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“BACE1 null mice manifest alterations in hippocampal synaptic plasticity as well as in performance on tests of cognition and emotion”

Emotional Function Testing

Emotional alterations were assessed in BACE1 null mice and transgenic controls

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Note: Emotional alterations in BACE1 null mice were not prevented by coexpressing APPswe;PS1 ΔE9 transgenes

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“memory deficits but not emotional alterations in BACE1 –/– mice are prevented by coexpressing APPswe;PS1 ΔE9 transgenes”

Hippocampal Synaptic Plasticity Assessment

Alterations in hippocampal synaptic plasticity were measured in BACE1 null mice

Not specified in provided textNot specified in provided text

Note: Specific methodology for synaptic plasticity measurement not detailed in provided excerpt

View evidence from paper

“BACE1 null mice manifest alterations in hippocampal synaptic plasticity as well as in performance on tests of cognition and emotion”