Source Paper
Mice Lacking the ERK1 Isoform of MAP Kinase Are Unimpaired in Emotional Learning
Joel C. Selcher, Tanya Nekrasova, Richard Paylor, Gary E. Landreth, J. David Sweatt
Learning & Memory • 2001
Contextual Fear Conditioning
Objective: Measurement of acquisition and retention of fear memory to context at 24 hours and 2 weeks post-training in ERK1-null and wild-type mice
Gather these items before starting the experiment. Check off items as you prepare.
Equipment1
Not explicitly stated • Not explicitly stated • Not explicitly stated • Not mentioned
1 item available from ConductScience
Estimated: $5,900.00
As an Amazon Associate, we earn from qualifying purchases. Product links help support this free resource.
Protocol Steps
Contextual Fear Conditioning Training
Mice undergo fear conditioning training to establish baseline fear memory to context
Note: Training phase for acquisition of contextual fear memory
View evidence from paper
“acquisition or retention (24 h and 2 wk after training) of either contextual or cue fear conditioning”
24-Hour Retention Test
Assessment of contextual fear memory retention 24 hours after training
Note: First retention measurement timepoint
View evidence from paper
“retention (24 h and 2 wk after training) of either contextual or cue fear conditioning”
2-Week Retention Test
Assessment of contextual fear memory retention 2 weeks after training
Note: Second retention measurement timepoint
View evidence from paper
“retention (24 h and 2 wk after training) of either contextual or cue fear conditioning”
