Contextual Fear Conditioning
Objective: Evaluation of contextual fear memory in Mecp2 mutant mice to assess hippocampus-dependent learning and memory function
This is a Contextual Fear Conditioning protocol using mouse as the model organism. The procedure involves 1 procedural steps. Extracted from a 2006 paper published in Journal of Neuroscience.
Model and subjects
mouse • Mecp2 308 mutant mice • male • Not specified • Not specified • Not specified
Study window
Estimated timing pending
Core workflow
Contextual Fear Conditioning Test
Primary readouts
- Contextual fear memory performance
- Comparison between Mecp2 308/Y mutant males and control animals
Key equipment and reagents
Verified items
0
Direct vendor links
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Protocol Steps
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Contextual Fear Conditioning Test
Mice were subjected to contextual fear conditioning to evaluate hippocampus-dependent contextual fear memory
Note: This was one of three memory tasks performed; contextual fear memory was significantly impaired in Mecp2 308/Y mutant males
View evidence from paper
“Hippocampus-dependent spatial memory, contextual fear memory, and social memory were significantly impaired in Mecp2 308 mutant males”